{"id":"W2944743743","doi":"10.1016/j.neulet.2019.04.043","title":"DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters membrane dynamics of sorting nexin 1","year":2019,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Sorting nexin; Cell biology; Retromer; Chaperone (clinical); Biology; Mutant; Transport protein; Membrane protein; Mutation; Protein targeting; Wild type; Heat shock protein; Endosome; Genetics; Gene; Membrane; Intracellular; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629723,0.0001595235,0.0001793085,0.00008447521,0.00003912501,0.00002158743,0.0004306397,0.00009650074,0.00000353021],"category_scores_gemma":[0.00006517881,0.000157156,0.00007242492,0.0002683988,0.0001726143,0.00001217852,0.0001366074,0.0001494805,0.000002938718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002388656,"about_ca_system_score_gemma":0.00004604438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008640541,"about_ca_topic_score_gemma":0.00005688293,"domain_scores_codex":[0.9985839,0.00005158299,0.0002919123,0.0005045916,0.0001968581,0.0003711836],"domain_scores_gemma":[0.9993466,0.0000119866,0.0001485776,0.0004132034,0.00002110711,0.00005855457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004190751,0.00001599487,0.02644358,0.0000170665,0.000001676749,0.000004860513,0.00002239154,0.002282908,0.9699576,0.00008466127,0.00003223134,0.001095065],"study_design_scores_gemma":[0.001768868,0.0005236915,0.08609558,0.00003938802,0.00001311823,0.00005474862,0.00008185027,0.02715009,0.8804328,0.000166988,0.002989613,0.0006831996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965729,0.00002023392,0.001621957,0.0008867989,0.0003927391,0.0002554268,0.00001617981,0.00001305029,0.0002207767],"genre_scores_gemma":[0.9948171,0.00002808024,0.0003471289,0.004657711,0.00003994296,0.000008659744,0.00003123618,0.00001778509,0.00005229301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0895248,"threshold_uncertainty_score":0.6408635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006543915378737677,"score_gpt":0.230764481994988,"score_spread":0.2242205666162504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}