{"id":"W2944745527","doi":"10.1371/journal.ppat.1007736","title":"A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle","year":2019,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Commission; Deutsche Forschungsgemeinschaft; Institut national de la recherche scientifique","keywords":"Biology; Dengue virus; Viral replication; RNA; Dengue fever; Endoplasmic reticulum; Virology; Cell biology; Host factor; Virus; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003581622,0.0001587766,0.0003230374,0.00004819242,0.0001594466,0.00002972455,0.0001546295,0.0001007248,0.00001702079],"category_scores_gemma":[0.0006231564,0.00009826689,0.0002055225,0.0001070216,0.00006544135,0.0001935255,0.00004400757,0.00009757152,0.00000475216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000686327,"about_ca_system_score_gemma":0.00006861688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004927492,"about_ca_topic_score_gemma":0.000008827642,"domain_scores_codex":[0.9986443,0.0000518874,0.000470477,0.0004157613,0.0002287978,0.0001887812],"domain_scores_gemma":[0.9979101,0.000189724,0.0004968717,0.001018404,0.000328326,0.00005661672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001811574,0.00006724288,0.0005045622,0.0003776741,0.00009334684,5.285978e-8,0.0007750653,0.000002983405,0.9839972,0.0005503097,0.00006877087,0.01175123],"study_design_scores_gemma":[0.006897553,0.0003368788,0.009613992,0.0001880823,0.0008377747,0.00001675101,0.0003737956,0.03537598,0.9452707,0.0004718452,0.0004568897,0.0001597933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810617,0.00007106608,0.007012691,0.002439444,0.00007969986,0.008310199,0.0009376518,0.00003360258,0.00005392163],"genre_scores_gemma":[0.9965933,0.000009685181,0.0009694849,0.0003622162,0.0002184947,0.001269514,0.0002526554,0.00003048272,0.0002941744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03872652,"threshold_uncertainty_score":0.4007207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02529058043330333,"score_gpt":0.2698167357453784,"score_spread":0.2445261553120751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}