{"id":"W2944778810","doi":"10.1158/1541-7786.mcr-19-0020","title":"Reprogramming of Isocitrate Dehydrogenases Expression and Activity by the Androgen Receptor in Prostate Cancer","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; American Association for Cancer Research","keywords":"Prostate cancer; Androgen receptor; Cancer research; IDH1; Biology; Cancer; Reprogramming; Isocitrate dehydrogenase; Gene knockdown; Cancer cell; Oncogene; Cell cycle; Cell; Apoptosis; Gene; Genetics; Enzyme; Mutation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001592233,0.0001521916,0.000220306,0.0003912489,0.000147058,0.0005141248,0.0001706889,0.0001539654,0.001392395],"category_scores_gemma":[0.0001604942,0.0001183416,0.000289178,0.0004374063,0.0001410149,0.0001237179,0.0002167632,0.0003653075,0.0004025463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004826634,"about_ca_system_score_gemma":0.0003077495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001869539,"about_ca_topic_score_gemma":0.002378541,"domain_scores_codex":[0.9998432,0.00001953343,0.00001003375,0.00004436227,0.00005199192,0.00003080995],"domain_scores_gemma":[0.9999068,0.00001564083,0.00002745847,0.00001539161,0.00001603166,0.00001881028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003148389,0.00005042839,0.008442578,0.000157527,0.00005089772,0.00009440447,0.00003725043,0.0004062236,0.9792045,0.0003034581,0.0004570765,0.01048086],"study_design_scores_gemma":[0.00003998508,0.0004952424,0.2612561,0.0000269741,0.0001315928,0.001330765,0.000176301,0.003266355,0.7100688,0.0005663804,0.02259386,0.00004767703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750021,0.01170685,0.004203453,0.0002763682,0.000103528,0.00002982466,0.005874875,0.0003094852,0.002493436],"genre_scores_gemma":[0.9940909,0.001821853,0.0006827957,0.00007014488,0.00001257963,0.000009517388,0.002309976,0.00001654866,0.0009857331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001869539,"threshold_uncertainty_score":0.004658043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03937521247506486,"score_gpt":0.3923505640991219,"score_spread":0.352975351624057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}