{"id":"W2944789729","doi":"10.1016/j.jpba.2019.05.006","title":"Development and validation of an absolute protein assay for the simultaneous quantification of fourteen CYP450s in human microsomes by HPLC-MS/MS-based targeted proteomics","year":2019,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Chromatography; Formic acid; Microsome; Electrospray ionization; Tandem mass spectrometry; Mass spectrometry; High-performance liquid chromatography; Selected reaction monitoring; Electrospray; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00305297,0.0002025846,0.0006329852,0.0003964458,0.0001183335,0.00002231083,0.0002830795,0.000232535,0.0001989968],"category_scores_gemma":[0.0001588574,0.0001367397,0.0001798423,0.0005994471,0.0003681261,0.00009010849,0.00005243977,0.0004753876,8.043752e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003225349,"about_ca_system_score_gemma":0.0001281263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001716778,"about_ca_topic_score_gemma":0.000005907919,"domain_scores_codex":[0.9974623,0.0004220292,0.001179454,0.0002548272,0.0003912998,0.0002901445],"domain_scores_gemma":[0.9978489,0.0007263247,0.0007116596,0.0001190617,0.0002898693,0.0003041858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007628995,0.0008784204,0.003021308,0.0001968232,0.00102142,0.000005044325,0.0002448671,0.001124413,0.9669152,0.00006878627,0.00004500755,0.02571581],"study_design_scores_gemma":[0.003258739,0.0002195574,0.00160215,0.00002561574,0.001467175,0.00000501854,0.00005724501,0.1747891,0.7950126,0.0001171156,0.02328176,0.0001638778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899116,0.001394057,0.006636173,0.001072368,0.0001271122,0.0007203703,0.0001241577,0.000005363685,0.000008864369],"genre_scores_gemma":[0.9948448,0.0002295186,0.004446053,0.0002253333,0.00008822566,0.00002424737,0.00007214335,0.00001282061,0.00005684269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1736647,"threshold_uncertainty_score":0.5576081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05859933814958836,"score_gpt":0.4053547009288324,"score_spread":0.3467553627792441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}