{"id":"W2944799162","doi":"10.1016/j.jmb.2019.04.047","title":"Prp8 in a Reduced Spliceosome Lacks a Conserved Toggle that Correlates with Splicing Complexity across Diverse Taxa","year":2019,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Northern British Columbia; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Spliceosome; RNA splicing; Genetics; Intron; Minor spliceosome; Biology; Computational biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169987,0.0003793507,0.0004233374,0.0006085748,0.0003531807,0.0003375407,0.000489687,0.0007184952,0.002345701],"category_scores_gemma":[0.0002959594,0.0002285132,0.0004251877,0.0002552733,0.0004079636,0.0001747663,0.0003903042,0.0007425019,0.000686613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002149642,"about_ca_system_score_gemma":0.0001417248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005357867,"about_ca_topic_score_gemma":0.0008428503,"domain_scores_codex":[0.9998147,0.00002906193,0.00002963767,0.00004707285,0.00005278671,0.00002669254],"domain_scores_gemma":[0.999518,0.00008858852,0.00013862,0.00006637556,0.00004890009,0.0001396187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002269571,0.00003718917,0.001059904,0.00002125742,0.00003145459,0.0006443601,0.00002307898,0.0001207036,0.9967206,0.0002136484,0.00007520147,0.0008256052],"study_design_scores_gemma":[0.0002063369,0.00103729,0.1744272,0.00004859941,0.00028232,0.01714723,0.000264058,0.007622699,0.7907754,0.001609051,0.00650515,0.00007457166],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981628,0.0001309474,0.0009092782,0.00005891833,0.000017121,0.000008708441,0.0002474253,0.00005164975,0.0004130813],"genre_scores_gemma":[0.9974887,0.00004365908,0.0009657278,0.00006409035,0.00001350975,0.00001116931,0.0006300712,0.00004060069,0.0007423649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002345701,"threshold_uncertainty_score":0.00784719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0258835111437121,"score_gpt":0.3153018927701897,"score_spread":0.2894183816264775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}