{"id":"W2944803493","doi":"10.1101/635318","title":"Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Public Health Ontario; BC Cancer Agency; Princess Margaret Cancer Centre; University of Toronto; University Health Network; Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"National Cancer Institute; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; University of Bristol; Canadian Institutes of Health Research; Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute for Health and Care Research; U.S. Department of Health and Human Services; National Institutes of Health; Cancer Research UK; University Hospitals Bristol NHS Foundation Trust; World Health Organization; Roy Castle Lung Cancer Foundation; Université Laval","keywords":"Lung cancer; Vital capacity; Medicine; Mendelian randomization; Pulmonary function testing; Odds ratio; Internal medicine; Oncology; Carcinogenesis; Lung; Cancer; Diffusing capacity; Lung function; Biology; Genotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000401809,0.0002433876,0.000260205,0.0004313559,0.0001419411,0.0003151955,0.0001314828,0.0003450283,0.004081189],"category_scores_gemma":[0.0007512248,0.00009329367,0.0003149945,0.0003659054,0.0002944634,0.0001069265,0.0002623386,0.0003114568,0.0003908488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001716905,"about_ca_system_score_gemma":0.0001472484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005188037,"about_ca_topic_score_gemma":0.0003044893,"domain_scores_codex":[0.9997873,0.00007889154,0.000009706273,0.00004505087,0.00004476585,0.0000343234],"domain_scores_gemma":[0.9996698,0.000136789,0.0001094437,0.00003574698,0.00001486457,0.00003344765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002969654,0.0004433559,0.5164112,0.0004062697,0.0007915978,0.004209405,0.000254249,0.00283354,0.413392,0.006527693,0.004636367,0.04712468],"study_design_scores_gemma":[0.000173524,0.0003418775,0.9201204,0.00005322764,0.0003998787,0.005311515,0.0001949504,0.004910877,0.05664153,0.00792955,0.003900332,0.00002239388],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911823,0.001273545,0.003687157,0.0006192352,0.00004221424,0.00001350211,0.0009994759,0.0001285228,0.002054117],"genre_scores_gemma":[0.9975646,0.0003002311,0.0009462416,0.00009142466,0.00002278417,0.000007316452,0.0003115277,0.00001272664,0.0007431068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004081189,"threshold_uncertainty_score":0.01365292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008942711262030032,"score_gpt":0.2346002167441115,"score_spread":0.2256575054820815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}