{"id":"W2944804656","doi":"10.3390/genes10050364","title":"Outcome Definition Influences the Relationship between Genetic Polymorphisms of ERCC1, ERCC2, SLC22A2 and Cisplatin Nephrotoxicity in Adult Testicular Cancer Patients","year":2019,"lang":"en","type":"article","venue":"Genes","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University Health Network; BC Children's Hospital; University of Toronto; Princess Margaret Cancer Centre; BC Cancer Agency; University of British Columbia","funders":"BC Children's Hospital; Michael Smith Health Research BC; Lembaga Pengelola Dana Pendidikan; Genome British Columbia; Canadian Institutes of Health Research; Genome Canada","keywords":"ERCC2; ERCC1; Cisplatin; Nephrotoxicity; Testicular cancer; Oncology; Medicine; Biology; Genetics; Internal medicine; Genotype; Cancer; Single-nucleotide polymorphism; Chemotherapy; Gene; DNA repair; Nucleotide excision repair; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525259,0.000144093,0.0002655337,0.0001219415,0.00005491038,0.00001255535,0.0000800451,0.0001401094,0.00004895814],"category_scores_gemma":[0.0003841334,0.0001101246,0.00004415288,0.0003067615,0.00009928735,0.00008909092,0.00002919347,0.000176709,0.00001608506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007195416,"about_ca_system_score_gemma":0.0000640281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005439288,"about_ca_topic_score_gemma":0.0001406985,"domain_scores_codex":[0.9987883,0.00007581234,0.0004443873,0.000230878,0.0002912577,0.0001693479],"domain_scores_gemma":[0.999013,0.0003881647,0.000183622,0.0002394859,0.0001190287,0.00005666896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002303467,0.00003922318,0.9546939,0.00008063562,0.00001535026,6.408961e-7,0.0004569317,0.00001857707,0.04203983,0.00006281451,0.000005091355,0.002563942],"study_design_scores_gemma":[0.001294867,0.0001194559,0.9468803,0.0001565501,0.00005776936,0.00000276694,0.00006584861,0.00005229854,0.05057739,0.0006753264,0.000007614074,0.0001098491],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981424,0.0002812989,0.00002407046,0.0005769971,0.00005547416,0.0008143994,0.00002888128,0.00002007455,0.0000564205],"genre_scores_gemma":[0.9985012,0.00003759834,0.0008804913,0.0004064094,0.00006474373,0.00003733559,0.00002650186,0.00002037564,0.00002530673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008537562,"threshold_uncertainty_score":0.449075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04438073159412148,"score_gpt":0.2946439162843522,"score_spread":0.2502631846902307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}