{"id":"W2944804656","doi":"10.3390/genes10050364","title":"Outcome Definition Influences the Relationship between Genetic Polymorphisms of ERCC1, ERCC2, SLC22A2 and Cisplatin Nephrotoxicity in Adult Testicular Cancer Patients","year":2019,"lang":"en","type":"article","venue":"Genes","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University Health Network; BC Children's Hospital; University of Toronto; Princess Margaret Cancer Centre; BC Cancer Agency; University of British Columbia","funders":"BC Children's Hospital; Michael Smith Health Research BC; Lembaga Pengelola Dana Pendidikan; Genome British Columbia; Canadian Institutes of Health Research; Genome Canada","keywords":"ERCC2; ERCC1; Cisplatin; Nephrotoxicity; Testicular cancer; Oncology; Medicine; Biology; Genetics; Internal medicine; Genotype; Cancer; Single-nucleotide polymorphism; Chemotherapy; Gene; DNA repair; Nucleotide excision repair; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001383046,0.000263002,0.0004130827,0.0004548435,0.0003193257,0.0006804778,0.000375575,0.0002935684,0.0009564551],"category_scores_gemma":[0.005426372,0.0001218235,0.0006787171,0.001215079,0.0003210813,0.0003607472,0.000423887,0.0005235024,0.00008678585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005021268,"about_ca_system_score_gemma":0.0005254258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006038039,"about_ca_topic_score_gemma":0.01001537,"domain_scores_codex":[0.9988856,0.0004166673,0.0001437675,0.0002192464,0.0002094823,0.0001253543],"domain_scores_gemma":[0.996314,0.000890727,0.001848521,0.000236552,0.0003410187,0.0003692059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002271739,0.00001714234,0.9979971,0.00001557396,0.0001122794,0.00004681935,0.00004968978,0.00005267185,0.0001891939,0.00002379472,0.00008421731,0.001184253],"study_design_scores_gemma":[0.00001781307,0.0001089108,0.9988081,0.000009925309,0.000130985,0.0002473493,0.00007487863,0.0002176483,0.0001386393,0.00007286023,0.0001672014,0.000005690008],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986058,0.0006492587,0.0001722718,0.00007353305,0.000009590641,0.000007018121,0.0002509403,0.00000267244,0.0002289605],"genre_scores_gemma":[0.9995286,0.00006545747,0.00005514701,0.00002820937,0.00001109739,0.000004349872,0.0002496593,0.000002256755,0.00005515958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006038039,"threshold_uncertainty_score":0.01200581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04438073159412148,"score_gpt":0.2946439162843522,"score_spread":0.2502631846902307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}