{"id":"W2944858420","doi":"10.1161/circheartfailure.118.005544","title":"Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure","year":2019,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"National Institute for Health and Care Research","keywords":"Surrogate endpoint; Proenkephalin; Opioid; Medicine; Heart failure; Internal medicine; Cardiology; Opioid peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001105263,0.0003926101,0.0004133708,0.0006015779,0.0001791694,0.0006635981,0.0002364505,0.0002589407,0.000508749],"category_scores_gemma":[0.001348094,0.00008309817,0.0002663826,0.0005847583,0.0001957925,0.0002622913,0.000531444,0.0004249693,0.00008588043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002802174,"about_ca_system_score_gemma":0.0002695331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008948821,"about_ca_topic_score_gemma":0.001453732,"domain_scores_codex":[0.9996936,0.0001229015,0.00002306843,0.00006589962,0.00006536534,0.00002910631],"domain_scores_gemma":[0.9990959,0.0001897692,0.0003886048,0.00006073082,0.0001094414,0.0001555419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001400716,0.00008827241,0.9805247,0.00007143311,0.0002334864,0.00007922307,0.00005570011,0.0009331541,0.003397481,0.00007142167,0.0003128621,0.01283151],"study_design_scores_gemma":[0.0000297583,0.0003977046,0.993143,0.00001886257,0.0001056076,0.0002558864,0.00004936239,0.004625172,0.0008225198,0.000156432,0.0003849812,0.00001066442],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997146,0.001183699,0.0007821851,0.00007620741,0.00001143033,0.00001484374,0.0003901166,0.00001457073,0.0003809427],"genre_scores_gemma":[0.9987356,0.0001422403,0.000700608,0.00002904383,0.00001602997,0.00001068364,0.0002824308,0.000001808785,0.00008148675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001105263,"threshold_uncertainty_score":0.005845249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853793108046331,"score_gpt":0.2705007064691696,"score_spread":0.2519627753887063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}