{"id":"W2944858420","doi":"10.1161/circheartfailure.118.005544","title":"Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure","year":2019,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"National Institute for Health and Care Research","keywords":"Surrogate endpoint; Proenkephalin; Opioid; Medicine; Heart failure; Internal medicine; Cardiology; Opioid peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003539008,0.0004254751,0.0007745618,0.0004423083,0.0001214958,0.00009029207,0.0001096712,0.000293773,0.0006614944],"category_scores_gemma":[0.00003286072,0.000397549,0.0002234243,0.0006245036,0.00005699587,0.0004820362,0.00006932725,0.0003837133,0.001555823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003772448,"about_ca_system_score_gemma":0.0002292372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003886273,"about_ca_topic_score_gemma":0.0002556161,"domain_scores_codex":[0.9970624,0.0001648405,0.0006443757,0.0008399682,0.0006665729,0.0006218441],"domain_scores_gemma":[0.9982883,0.00008217816,0.0001181528,0.0008385488,0.0003115781,0.0003612969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006035778,0.001247247,0.7979288,0.001808508,0.0003622196,0.0001582039,0.001135274,0.001364304,0.1390521,0.004516678,0.05137091,0.0004521618],"study_design_scores_gemma":[0.006719927,0.0004957535,0.3554095,0.0008710828,0.000134126,0.0004734306,0.001837413,0.00403297,0.000775067,0.00003828793,0.6286936,0.000518774],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979212,0.0001156419,0.0001453914,0.01529171,0.0002890253,0.00386022,0.00001671958,0.0003585858,0.000710634],"genre_scores_gemma":[0.9834473,0.00000201678,0.01355502,0.001074303,0.0002370118,0.0001640204,0.0003905499,0.00007315823,0.001056646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5773228,"threshold_uncertainty_score":0.9998477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853793108046331,"score_gpt":0.2705007064691696,"score_spread":0.2519627753887063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}