{"id":"W2944870159","doi":"10.1002/jbm4.10205","title":"Downregulation of FGF Signaling by <i>Spry4</i> Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar","year":2019,"lang":"en","type":"article","venue":"JBMR Plus","topic":"dental development and anomalies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Toronto","funders":"National Institutes of Health; National Institute of Dental and Craniofacial Research; École Normale Supérieure de Lyon","keywords":"Fibroblast growth factor; Downregulation and upregulation; Phenotype; Cell biology; Dentition; Signal transduction; Biology; Transgene; Regulator; Amelogenesis; Ameloblast; Keratin 14; Genetically modified mouse; Enamel paint; Genetics; Gene; Dentistry; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001974985,0.0005606152,0.0002921514,0.0008006918,0.0002585395,0.0004783793,0.0003162077,0.0005612441,0.002257924],"category_scores_gemma":[0.0001467798,0.0005041506,0.000385111,0.0001802623,0.000540305,0.0002213007,0.0004083628,0.0008939523,0.0009779177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004476078,"about_ca_system_score_gemma":0.0002984955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001218153,"about_ca_topic_score_gemma":0.001293051,"domain_scores_codex":[0.9996897,0.00003497373,0.00003462434,0.00006569292,0.0001049235,0.00007004963],"domain_scores_gemma":[0.9996377,0.00005359356,0.0001633455,0.00003032912,0.00001897531,0.00009607682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003766331,0.000008864715,0.00009935156,0.000006158976,0.000002213988,0.00007783675,0.00000484099,0.00003023833,0.9994515,0.00005602052,0.00001822331,0.0002070913],"study_design_scores_gemma":[0.00001241094,0.00007550633,0.0043889,0.000003758103,0.000009602429,0.0004133417,0.00002061315,0.0005680397,0.9934658,0.00005089203,0.0009865925,0.000004428224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932665,0.0005277318,0.002945445,0.0001198767,0.00003369475,0.00002185434,0.0006669374,0.0003148347,0.002103183],"genre_scores_gemma":[0.9883679,0.0004909436,0.002807865,0.00006015312,0.00001253717,0.00003195765,0.0005950203,0.0001844356,0.007449393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002257924,"threshold_uncertainty_score":0.007553458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00548584171946185,"score_gpt":0.2156146936450996,"score_spread":0.2101288519256378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}