{"id":"W2944932688","doi":"10.1083/jcb.201805155","title":"PTEN reduces endosomal PtdIns(4,5)P2 in a phosphatase-independent manner via a PLC pathway","year":2019,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fondation du Grand défi Pierre Lavoie; Association du Syndrome de Lowe; Centre National de la Recherche Scientifique; Institut Pasteur; Lowe Syndrome Trust; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"PTEN; Biology; Cytokinesis; Endosome; Phosphatase; Cell biology; Mitosis; Suppressor; Cancer research; Signal transduction; Cell; PI3K/AKT/mTOR pathway; Phosphorylation; Genetics; Gene; Cell division; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001001493,0.0004013639,0.0001573513,0.0003628385,0.0001265264,0.0003893761,0.0002440615,0.0001881406,0.0008026529],"category_scores_gemma":[0.000125007,0.0001382122,0.0002196445,0.0001692571,0.0003017169,0.0002184138,0.0003197372,0.0003780752,0.0002222135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003696501,"about_ca_system_score_gemma":0.0002972911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007803433,"about_ca_topic_score_gemma":0.0008541283,"domain_scores_codex":[0.9998788,0.00001444166,0.00001111956,0.00002440233,0.00004708593,0.0000241888],"domain_scores_gemma":[0.9999472,0.000007989759,0.00001658276,0.000006385172,0.000005985052,0.00001584486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006500069,0.00002174362,0.0002166758,0.0000332734,0.000008826972,0.00009092093,0.000006711006,0.0001154077,0.9973111,0.0003600232,0.00007269742,0.001697732],"study_design_scores_gemma":[0.00002284628,0.0001040202,0.002058155,0.000002238364,0.00001338763,0.0002229627,0.000009047522,0.0009436596,0.9941905,0.00008951634,0.002340569,0.000003117165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836337,0.002104946,0.00910279,0.000403272,0.00004578047,0.00004177764,0.0005565867,0.0003406173,0.00377055],"genre_scores_gemma":[0.9936972,0.001351565,0.001608862,0.00006370733,0.000008348148,0.00003504971,0.0003630382,0.00002221721,0.002850043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008026529,"threshold_uncertainty_score":0.002685189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005968267660655049,"score_gpt":0.2079071487233937,"score_spread":0.2019388810627387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}