{"id":"W2944950731","doi":"10.1093/nar/gkz395","title":"DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"National Institute of Environmental Health Sciences; National Institutes of Health; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Alberta Innovates - Technology Futures","keywords":"AlkB; 5-Methylcytosine; 5-Hydroxymethylcytosine; Biology; DNA methylation; Epigenetics; DNA; Base excision repair; Biochemistry; DNA repair; Cytosine; DNA glycosylase; Genetics; Gene; Molecular biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002571758,0.0004478491,0.0005626167,0.0007062034,0.0002086295,0.0001482843,0.0004101411,0.0004740788,0.00007923444],"category_scores_gemma":[0.000669003,0.0004376122,0.0001185939,0.0009830769,0.0003052737,0.00003546194,0.0009263309,0.00057299,0.00007857523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000090109,"about_ca_system_score_gemma":0.0001883379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002395436,"about_ca_topic_score_gemma":0.0001063361,"domain_scores_codex":[0.9956861,0.0004535805,0.0006285353,0.001349669,0.0007894762,0.001092649],"domain_scores_gemma":[0.9978764,0.0001897671,0.00009494996,0.001016563,0.0003440595,0.0004782754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006364258,0.0001263404,0.01231631,0.00008478855,0.00005781584,0.00001201161,0.0001916129,0.00002148401,0.9773554,0.0002548807,0.0006151512,0.00832781],"study_design_scores_gemma":[0.002073014,0.001171993,0.0337133,0.0000647421,0.00001738419,0.00001704618,0.0002100347,0.000704616,0.9158425,0.000384339,0.04525048,0.0005505547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861587,0.007985295,0.0001367773,0.001252327,0.0001421212,0.001152083,0.00004043616,0.00005463927,0.003077646],"genre_scores_gemma":[0.9889154,0.002296394,0.005953416,0.0003201226,0.0002859655,0.00008948937,0.0001087651,0.0001129085,0.001917496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06151288,"threshold_uncertainty_score":0.9998075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01896872147037301,"score_gpt":0.309463936309679,"score_spread":0.290495214839306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}