{"id":"W2944950731","doi":"10.1093/nar/gkz395","title":"DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"National Institute of Environmental Health Sciences; National Institutes of Health; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Alberta Innovates - Technology Futures","keywords":"AlkB; 5-Methylcytosine; 5-Hydroxymethylcytosine; Biology; DNA methylation; Epigenetics; DNA; Base excision repair; Biochemistry; DNA repair; Cytosine; DNA glycosylase; Genetics; Gene; Molecular biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000189221,0.0004421902,0.0002613502,0.000143797,0.0002981375,0.0002401863,0.0002445401,0.0004702673,0.001136704],"category_scores_gemma":[0.0001776152,0.00016716,0.0002991394,0.0001266248,0.0002329197,0.0003202858,0.0002763915,0.0003709523,0.0006183385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000369479,"about_ca_system_score_gemma":0.0002236662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092658,"about_ca_topic_score_gemma":0.000996453,"domain_scores_codex":[0.9998734,0.00001719015,0.000005333849,0.00003485149,0.0000426582,0.00002645401],"domain_scores_gemma":[0.9999003,0.00001596021,0.00003160613,0.00001014026,0.00002198231,0.00001997572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001783937,0.00006086874,0.003024246,0.0002051332,0.00005061141,0.00009984457,0.00007294871,0.00112824,0.97942,0.001861694,0.0001903214,0.0137078],"study_design_scores_gemma":[0.0000150763,0.0001811875,0.004014478,0.000007874103,0.00001959135,0.0002453382,0.00006543697,0.003983045,0.9829327,0.0006663764,0.007858666,0.00001017837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9508697,0.006590455,0.03621722,0.0003967976,0.00007552517,0.0000787801,0.0002998032,0.0002781379,0.005193464],"genre_scores_gemma":[0.9841815,0.001176336,0.009199205,0.00006325174,0.000008665872,0.00002141715,0.0003756514,0.00001924679,0.004954701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001136704,"threshold_uncertainty_score":0.003802598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01896872147037301,"score_gpt":0.309463936309679,"score_spread":0.290495214839306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}