{"id":"W2944956458","doi":"10.1002/cpt.1496","title":"Modulation of <scp>CYP</scp>450 Activities in Patients With Type 2 Diabetes","year":2019,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Tolbutamide; CYP2B6; CYP2C19; CYP1A2; Chlorzoxazone; Type 2 diabetes; Pharmacology; CYP3A; CYP2D6; CYP2C9; Medicine; Diabetes mellitus; CYP2E1; Internal medicine; Dextromethorphan; Cytochrome P450; Endocrinology; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001181108,0.0004153725,0.0008711079,0.0002505065,0.00009045581,0.00001319157,0.0005183363,0.000642933,0.0006216791],"category_scores_gemma":[0.00003337422,0.0003667115,0.0001816137,0.0005337138,0.0005825472,0.00018427,0.00016126,0.001435429,0.0001601528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005582481,"about_ca_system_score_gemma":0.0001868956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002374339,"about_ca_topic_score_gemma":0.000002394481,"domain_scores_codex":[0.996094,0.001201897,0.001032655,0.0005909737,0.0003073518,0.0007731523],"domain_scores_gemma":[0.996282,0.002304821,0.0005361487,0.0003265216,0.0002992004,0.0002512392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007537919,0.002248553,0.925004,0.00006538332,0.001026637,0.000004122039,0.0003841711,0.001910157,0.05578255,0.00003933702,0.001790439,0.01099083],"study_design_scores_gemma":[0.01770201,0.001610661,0.7850313,0.00002945473,0.001316522,0.000001230786,0.0001164592,0.01074151,0.05876317,0.0003084013,0.1240037,0.0003755721],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908662,0.001021962,0.00001145025,0.0002607579,0.005261615,0.001017642,0.00006400791,0.00006735394,0.001428949],"genre_scores_gemma":[0.9840257,0.001162551,0.0001822529,0.01365788,0.0003694766,0.00003276265,0.00005744157,0.00006893877,0.0004430651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1399727,"threshold_uncertainty_score":0.9998785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09800917757700978,"score_gpt":0.4363264046354054,"score_spread":0.3383172270583956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}