{"id":"W2944956458","doi":"10.1002/cpt.1496","title":"Modulation of <scp>CYP</scp>450 Activities in Patients With Type 2 Diabetes","year":2019,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Tolbutamide; CYP2B6; CYP2C19; CYP1A2; Chlorzoxazone; Type 2 diabetes; Pharmacology; CYP3A; CYP2D6; CYP2C9; Medicine; Diabetes mellitus; CYP2E1; Internal medicine; Dextromethorphan; Cytochrome P450; Endocrinology; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003491763,0.000270843,0.0004869036,0.0002596125,0.000219757,0.0003718082,0.00009118253,0.0002841127,0.0008001934],"category_scores_gemma":[0.0004960035,0.0001641737,0.0002835239,0.0003286519,0.0001683814,0.0001364082,0.0001369292,0.0004830732,0.0001540937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001578004,"about_ca_system_score_gemma":0.0001087242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000818088,"about_ca_topic_score_gemma":0.0009604613,"domain_scores_codex":[0.9997209,0.0001131965,0.00002312029,0.00006394088,0.00004385863,0.00003501527],"domain_scores_gemma":[0.9997377,0.00006547628,0.00007640767,0.00002656397,0.00002289272,0.00007103154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01856792,0.001051116,0.8545501,0.00009485708,0.0005306601,0.0006764358,0.0002503163,0.0002286911,0.09520331,0.00002991336,0.0002316141,0.02858507],"study_design_scores_gemma":[0.000163858,0.003873494,0.988926,0.00000420925,0.0001243042,0.0006115919,0.00006416433,0.000260762,0.005504136,0.00002183904,0.0004392906,0.000006460929],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986933,0.000827169,0.0001442432,0.00002019291,0.000005956747,0.000009234185,0.00008677689,0.000005097763,0.0002081215],"genre_scores_gemma":[0.9991167,0.0002596909,0.0001728508,0.00004515731,0.00001312923,0.000009104127,0.0001795077,0.000002482631,0.0002013611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000818088,"threshold_uncertainty_score":0.002676904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09800917757700978,"score_gpt":0.4363264046354054,"score_spread":0.3383172270583956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}