{"id":"W2944959809","doi":"10.1038/s41598-019-44346-5","title":"Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Prostate Cancer Canada; Deutsche Forschungsgemeinschaft; Movember Foundation","keywords":"Clusterin; Prostate cancer; PI3K/AKT/mTOR pathway; Protein kinase B; Cell biology; Stress fiber; Cancer research; Intracellular; Androgen receptor; Prostate; Downregulation and upregulation; Chemistry; Signal transduction; Biology; Medicine; Apoptosis; Cancer; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007002192,0.00012615,0.0001541178,0.0001298047,0.0002401856,0.0002468282,0.0001000067,0.0002011238,0.0016888],"category_scores_gemma":[0.0001020447,0.0000799505,0.0001731825,0.0001381552,0.000108525,0.0001680056,0.0001963996,0.0003694698,0.0001814757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000251383,"about_ca_system_score_gemma":0.0002629448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009126881,"about_ca_topic_score_gemma":0.001581976,"domain_scores_codex":[0.9999313,0.00001029111,0.000003186113,0.00001030118,0.0000253579,0.00001951372],"domain_scores_gemma":[0.9999307,0.00000783732,0.00001856776,0.000005633405,0.00001474059,0.00002240892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001734581,0.00004082731,0.0008151714,0.00005568354,0.000008945378,0.00007927098,0.00003214903,0.0001301867,0.9941881,0.0001676677,0.0001943581,0.00411427],"study_design_scores_gemma":[0.00003011438,0.001145743,0.05185595,0.00001357399,0.00005428104,0.001022448,0.0002119495,0.002363752,0.9329184,0.0004159263,0.009951436,0.00001637756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932244,0.002812106,0.001604795,0.0002126727,0.00004025853,0.00003210418,0.0002166664,0.00009394372,0.001763049],"genre_scores_gemma":[0.9973559,0.0006590399,0.0004921009,0.00004061973,0.000007314434,0.00001581498,0.0001639148,0.000008124556,0.001257019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0016888,"threshold_uncertainty_score":0.005649626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03287191297590095,"score_gpt":0.3137489674859211,"score_spread":0.2808770545100202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}