{"id":"W2944980803","doi":"10.1101/636167","title":"Electron cryomicroscopy observation of acyl carrier protein translocation in type I fungal fatty acid synthase","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Princess Margaret Cancer Foundation; Cancer Research Institute","keywords":"Acyl carrier protein; Fatty acid synthase; Transferase; ATP synthase; Substrate (aquarium); Acylation; Chemistry; Active site; Fatty acid; Stereochemistry; Fatty acid synthesis; Enzyme; Biochemistry; Catalysis; Biosynthesis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000899053,0.0001740565,0.00008922273,0.0001772217,0.0003963333,0.0002103822,0.0002337919,0.0003183769,0.00141185],"category_scores_gemma":[0.0001093173,0.0001317569,0.0001181232,0.0001041813,0.0003193238,0.000212903,0.0002197561,0.0007278638,0.0003420519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003592175,"about_ca_system_score_gemma":0.0001450693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001370455,"about_ca_topic_score_gemma":0.001241185,"domain_scores_codex":[0.9999734,0.000002521936,0.000001265899,0.000006499281,0.000008410101,0.000007803363],"domain_scores_gemma":[0.9999036,0.000031377,0.0000149403,0.00001589402,0.00001910993,0.00001524713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000103523,0.00002674008,0.0009806296,0.00004486507,0.000008929137,0.0006477209,0.00006933388,0.0004327881,0.9951874,0.000987235,0.0003082283,0.001202614],"study_design_scores_gemma":[0.00006021155,0.0002085865,0.04338016,0.0000464049,0.00002815736,0.00253693,0.0002750639,0.01302488,0.9313555,0.0007997224,0.008262146,0.00002216707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846497,0.001091517,0.008100189,0.0003684918,0.00004007692,0.00002103353,0.0005014475,0.0001334054,0.005094179],"genre_scores_gemma":[0.9883395,0.0006708163,0.007190583,0.00008361036,0.00001835861,0.00002897546,0.0004396295,0.00005442207,0.003174062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00141185,"threshold_uncertainty_score":0.004723132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645815909625169,"score_gpt":0.2377437084942797,"score_spread":0.221285549398028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}