{"id":"W2945047925","doi":"10.1038/s41564-019-0441-6","title":"VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1","year":2019,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University Health Network; Dalhousie University; Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research; University of Nottingham; Vanderbilt University","keywords":"Intracellular; Helicobacter pylori; Autophagy; Biology; Lysosome; Cell biology; Calcium in biology; Microbiology; Apoptosis; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001991975,0.0002210068,0.000275134,0.0001987976,0.0001460911,0.000465893,0.0002412627,0.0004714549,0.0008973334],"category_scores_gemma":[0.0002895534,0.0001587983,0.0002414797,0.00007103519,0.0003215978,0.0003457135,0.0005124286,0.000780027,0.0003892863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003353402,"about_ca_system_score_gemma":0.0001859775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001862684,"about_ca_topic_score_gemma":0.0002106805,"domain_scores_codex":[0.9998029,0.00002911115,0.00001175503,0.00003202963,0.00005213082,0.00007207815],"domain_scores_gemma":[0.9998184,0.0000218014,0.00004907585,0.00002641192,0.00001679502,0.00006750936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001024936,0.000009354626,0.000231323,0.00001213773,0.000002257277,0.00009352186,0.00001206488,0.00001866198,0.9985857,0.0002144108,0.00005083755,0.0006672316],"study_design_scores_gemma":[0.00009559468,0.0007541446,0.01341068,0.00001428208,0.00002954355,0.001857535,0.0001815979,0.003515612,0.9746118,0.0006007882,0.004913611,0.00001486198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961583,0.0005947668,0.002065625,0.0003602261,0.00005231328,0.000008577699,0.00009944496,0.0001041768,0.0005566134],"genre_scores_gemma":[0.9981639,0.0001679579,0.0007121828,0.00006538574,0.00002024312,0.000008382386,0.0001275206,0.00002754493,0.0007069054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008973334,"threshold_uncertainty_score":0.003001928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009103207324572055,"score_gpt":0.2351166959113223,"score_spread":0.2260134885867503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}