{"id":"W2945057570","doi":"10.1089/hum.2019.074","title":"<i>In Vitro</i> Validation of a CRISPR-Mediated CFTR Correction Strategy for Preclinical Translation in Pigs","year":2019,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Cas9; Biology; Viral vector; Genome editing; Genetic enhancement; Electroporation; Gene targeting; Gene; Computational biology; Molecular biology; Cell biology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002894918,0.0008781002,0.00056656,0.0006687145,0.0005620227,0.0008446879,0.0009934556,0.001307955,0.005220728],"category_scores_gemma":[0.001130809,0.0004809613,0.001052798,0.0003094545,0.0006568313,0.0005193091,0.0004305951,0.001149947,0.00359342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007249781,"about_ca_system_score_gemma":0.0007323557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001584512,"about_ca_topic_score_gemma":0.0013145,"domain_scores_codex":[0.998847,0.0003636643,0.000141609,0.0002152854,0.0002506291,0.0001817614],"domain_scores_gemma":[0.9989715,0.0001983575,0.0002509034,0.0001941803,0.0002672912,0.0001177706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002414526,0.0002151306,0.0002162234,0.0001847983,0.00001933752,0.0001947623,0.00006640162,0.0006448282,0.9931449,0.0005630291,0.0009644454,0.00354489],"study_design_scores_gemma":[0.00007451516,0.002669533,0.0008460771,0.00005317431,0.0000430751,0.0003122156,0.00003360718,0.001264792,0.9823554,0.0001127484,0.01220806,0.00002673997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6598698,0.003290448,0.2768945,0.002525314,0.001663005,0.006696746,0.01800109,0.004262703,0.02679632],"genre_scores_gemma":[0.768362,0.003877817,0.1700201,0.001446135,0.0001945646,0.006816287,0.02019376,0.001288258,0.02780106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005220728,"threshold_uncertainty_score":0.01746511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0329318824274944,"score_gpt":0.3606802611280246,"score_spread":0.3277483787005302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}