{"id":"W2945057570","doi":"10.1089/hum.2019.074","title":"<i>In Vitro</i> Validation of a CRISPR-Mediated CFTR Correction Strategy for Preclinical Translation in Pigs","year":2019,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Cas9; Biology; Viral vector; Genome editing; Genetic enhancement; Electroporation; Gene targeting; Gene; Computational biology; Molecular biology; Cell biology; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001994976,0.00008995988,0.0001333186,0.00006070126,0.00001108752,0.000005737624,0.00006306768,0.0001168036,0.00002372389],"category_scores_gemma":[0.00001001113,0.00009486814,0.00005934284,0.00006959347,0.00001153714,0.000004581902,0.000004754571,0.00005308462,0.000001876654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008498622,"about_ca_system_score_gemma":0.00002223528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002285746,"about_ca_topic_score_gemma":0.00003537789,"domain_scores_codex":[0.9993196,0.00003523567,0.0002620799,0.0001989976,0.00006012191,0.0001239611],"domain_scores_gemma":[0.9997227,0.00002730167,0.0000533242,0.0001461932,0.0000316988,0.00001875291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003533334,0.00007450176,0.001193156,0.0000142403,0.000009971962,1.481667e-7,0.0001240131,0.005654645,0.9901455,0.000003136381,0.00006189027,0.00236544],"study_design_scores_gemma":[0.002092188,0.0004725595,0.005333992,0.000009588806,0.000002562497,0.000001100014,0.0000339295,0.001674578,0.9893811,0.00006326685,0.0008289214,0.000106255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935166,0.0004258283,0.005230695,0.00002041446,0.0001674305,0.0005002204,0.00001025212,0.000006083291,0.0001224261],"genre_scores_gemma":[0.9989164,0.0001394375,0.0003225513,0.00004006008,0.00008829776,0.00004241015,0.0003062984,0.00001694073,0.0001275979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005399756,"threshold_uncertainty_score":0.3868611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0329318824274944,"score_gpt":0.3606802611280246,"score_spread":0.3277483787005302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}