{"id":"W2945063373","doi":"10.1038/s41467-019-10101-7","title":"Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":260,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Institute of Environmental Health Sciences; National Institute on Drug Abuse; National Institute on Aging; Medical Research Council; Canadian Institutes of Health Research; National Human Genome Research Institute; Alzheimer's Society; Fondation Brain Canada; National Institutes of Health; National Institute of Mental Health; Translational Genomics Research Institute; Rush University; Van Andel Research Institute; Brain and Behavior Research Foundation; National Cancer Institute; Illinois Department of Public Health; Krembil Foundation; Scottish Rite Charitable Foundation of Canada; U.S. Department of Defense","keywords":"Enhancer; Epigenetics; DNA methylation; CpG site; Biology; Methylation; Transcriptome; Epigenomics; Neuroscience; Alzheimer's disease; Genetics; Gene; Gene expression; Disease; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001207226,0.0001432062,0.0002433565,0.0004037053,0.000135805,0.000187871,0.0001345189,0.0001360938,0.001151484],"category_scores_gemma":[0.0002775259,0.0001107625,0.0001377284,0.0002198439,0.0001433518,0.0001266548,0.0002554269,0.0002044572,0.0001450085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001207936,"about_ca_system_score_gemma":0.00008512412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008075052,"about_ca_topic_score_gemma":0.002250994,"domain_scores_codex":[0.9999187,0.000007882343,0.000005569088,0.00003343139,0.00002059888,0.00001373755],"domain_scores_gemma":[0.9998279,0.00003147279,0.00008034531,0.00001516175,0.00002387019,0.00002131718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004970079,0.00003094853,0.08498003,0.00009596762,0.0001097751,0.0001966065,0.00018206,0.0001738409,0.8979048,0.0002184285,0.0001138576,0.01549673],"study_design_scores_gemma":[0.00001230212,0.0001487709,0.9173712,0.00001797644,0.00007631865,0.001161439,0.0001081843,0.0005020394,0.07828148,0.0005597123,0.001751291,0.00000942835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969218,0.0009340171,0.001118318,0.0000286274,0.000003797942,0.000003881583,0.0003728126,0.00002542071,0.0005912274],"genre_scores_gemma":[0.9981173,0.0002891071,0.0006243044,0.00001836117,0.000003787441,0.0000053165,0.0003169065,0.000006189851,0.0006187689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001151484,"threshold_uncertainty_score":0.003852069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01108686164435367,"score_gpt":0.2822584941270442,"score_spread":0.2711716324826905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}