{"id":"W2945085657","doi":"10.1097/mbc.0000000000000746","title":"Clinical and genetic factors influencing acenocoumarol dosing","year":2018,"lang":"en","type":"article","venue":"Blood Coagulation & Fibrinolysis","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Mount Sinai Hospital","funders":"Universidad Nacional de Rosario","keywords":"Acenocoumarol; Dosing; VKORC1; Medicine; CYP2C9; Warfarin; Anticoagulant; Cohort; Internal medicine; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000425735,0.0002827781,0.0004054513,0.0001820634,0.0004729187,0.00006023982,0.0002036262,0.0003347747,0.0005878961],"category_scores_gemma":[0.00008893868,0.0002762594,0.0001546427,0.000328243,0.0004549943,0.0001415628,0.0001807302,0.0003850658,0.00008761056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001255674,"about_ca_system_score_gemma":0.00006279621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003247284,"about_ca_topic_score_gemma":0.00001244405,"domain_scores_codex":[0.9976853,0.0004307887,0.0006794913,0.000522055,0.000217966,0.000464367],"domain_scores_gemma":[0.998659,0.0002808603,0.0002357688,0.0002842565,0.0001797916,0.0003603612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007896877,0.0001264504,0.8319609,0.00001797741,0.0003988208,0.00001008722,0.0007846576,0.0001898518,0.09293078,0.000134149,0.0001139494,0.07325341],"study_design_scores_gemma":[0.002560151,0.0001362669,0.8624022,0.00001326079,0.001283174,0.0000290136,0.00008039365,0.006283321,0.107176,0.00043573,0.01917275,0.0004277451],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959307,0.001065668,0.0002557746,0.0001289908,0.0008541186,0.0002953049,0.00002515412,0.0001224031,0.001321921],"genre_scores_gemma":[0.9962352,0.0005211557,0.001212724,0.0007450259,0.001032037,0.00001303743,0.00001363143,0.00003438304,0.0001928096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07282566,"threshold_uncertainty_score":0.9999689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1255061971591769,"score_gpt":0.4364540142748154,"score_spread":0.3109478171156386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}