{"id":"W2945092360","doi":"10.1016/j.biortech.2019.121484","title":"Metabolic engineering of Yarrowia lipolytica for the biosynthesis of crotonic acid","year":2019,"lang":"en","type":"article","venue":"Bioresource Technology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Andlinger Center for Energy and the Environment, Princeton University; Beijing Technology and Business University; Hubei University of Technology; National Natural Science Foundation of China; Canadian Association for the Study of the Liver","keywords":"Yarrowia; Biochemistry; Thioesterase; Metabolic engineering; Strain (injury); Escherichia coli; Chemistry; Alcohol dehydrogenase; Palmitoleic acid; Biology; Fatty acid; Biosynthesis; Yeast; Enzyme; Gene; Linoleic acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001668659,0.0001219532,0.0002206549,0.0001408228,0.00002003219,0.000002764879,0.0003014459,0.0002183884,0.00001117187],"category_scores_gemma":[0.000204596,0.00009084515,0.0001144113,0.0002373212,0.0001055232,0.000001339674,0.00007987679,0.00006820884,0.00000353065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003273391,"about_ca_system_score_gemma":0.00001974983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007436332,"about_ca_topic_score_gemma":0.000001106368,"domain_scores_codex":[0.9993184,0.000007385192,0.0002117754,0.0002195774,0.00005548433,0.0001874264],"domain_scores_gemma":[0.999262,0.00001184325,0.0001007931,0.0005411679,0.00006713123,0.00001705435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000311441,0.00002120191,0.0004874033,0.00005329916,0.00008602024,3.433432e-8,0.00001100663,0.000170258,0.9939315,0.001083925,0.00007326054,0.004050958],"study_design_scores_gemma":[0.0001930974,0.0001263936,0.0006429435,0.00001328306,0.00004291292,0.000007075339,0.000034112,0.0001662067,0.8892565,0.000008683348,0.1094207,0.00008807501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904997,0.006258447,0.002250874,0.0003336292,0.0001827547,0.0003898506,0.0000240423,0.0000377156,0.00002298698],"genre_scores_gemma":[0.9972048,0.000205645,0.002277392,0.00001191466,0.00009938147,0.00003366119,0.000005627079,0.00002191388,0.0001396535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1093474,"threshold_uncertainty_score":0.3704558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003422542854451519,"score_gpt":0.1916513352526746,"score_spread":0.1882287923982231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}