{"id":"W2945092360","doi":"10.1016/j.biortech.2019.121484","title":"Metabolic engineering of Yarrowia lipolytica for the biosynthesis of crotonic acid","year":2019,"lang":"en","type":"article","venue":"Bioresource Technology","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Andlinger Center for Energy and the Environment, Princeton University; Beijing Technology and Business University; Hubei University of Technology; National Natural Science Foundation of China; Canadian Association for the Study of the Liver","keywords":"Yarrowia; Biochemistry; Thioesterase; Metabolic engineering; Strain (injury); Escherichia coli; Chemistry; Alcohol dehydrogenase; Palmitoleic acid; Biology; Fatty acid; Biosynthesis; Yeast; Enzyme; Gene; Linoleic acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002687374,0.0005036377,0.0005032349,0.0003359488,0.0002300211,0.000578019,0.000304086,0.0003899461,0.0004700988],"category_scores_gemma":[0.0002244953,0.0002029169,0.0004628173,0.0004514434,0.0001885026,0.0002995087,0.0004785043,0.0007854021,0.0004856872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005380174,"about_ca_system_score_gemma":0.0004479683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001790122,"about_ca_topic_score_gemma":0.002287067,"domain_scores_codex":[0.9997715,0.00003675723,0.00003093699,0.00003599729,0.00007067197,0.0000540833],"domain_scores_gemma":[0.9998817,0.00002280663,0.00003371002,0.00001629263,0.00001899396,0.00002641843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005362391,0.00002028784,0.00008813939,0.00001755661,0.000004006034,0.00003316031,0.000008656532,0.0001010117,0.9989942,0.00006807877,0.000007681787,0.000603602],"study_design_scores_gemma":[0.00001068503,0.0001030036,0.001514194,0.0000063124,0.00002083135,0.0001158872,0.00003618588,0.0008084635,0.9960001,0.00003906351,0.001338199,0.000007237437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879009,0.0008595169,0.009156908,0.0002405376,0.00004307911,0.00006071149,0.000444603,0.0001010901,0.001192651],"genre_scores_gemma":[0.9858371,0.0008264898,0.008448191,0.00004044786,0.00001083542,0.00004729344,0.001009114,0.00006172647,0.003718883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001790122,"threshold_uncertainty_score":0.003903627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003422542854451519,"score_gpt":0.1916513352526746,"score_spread":0.1882287923982231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}