{"id":"W2945139022","doi":"10.1200/edbk_242229","title":"Patient-Centered Cancer Drug Development: Clinical Trials, Regulatory Approval, and Value Assessment","year":2019,"lang":"en","type":"article","venue":"American Society of Clinical Oncology Educational Book","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Queen's University","funders":"","keywords":"Expediting; Medicine; Clinical trial; Drug development; Cancer drugs; Drug; Intensive care medicine; Cancer; Regulatory science; Pharmacology; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1484461,0.00124196,0.002301762,0.002803213,0.001268933,0.01290622,0.00211221,0.007564339,0.007611209],"category_scores_gemma":[0.1973944,0.0007491219,0.0008859235,0.005665066,0.01202151,0.01119784,0.005318273,0.0116842,0.001807636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008389965,"about_ca_system_score_gemma":0.01988002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00183467,"about_ca_topic_score_gemma":0.002158522,"domain_scores_codex":[0.8581111,0.1154946,0.004096953,0.001754128,0.01951326,0.00102992],"domain_scores_gemma":[0.7768444,0.1837289,0.01249928,0.005499575,0.01669966,0.004728319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000204776,0.0002172267,0.001187053,0.002124193,0.0001214643,0.00009012768,0.0004331607,0.002765726,0.0001092152,0.4057553,0.1586858,0.428306],"study_design_scores_gemma":[0.0004133122,0.0005121327,0.002591111,0.008414516,0.000120912,0.0005189605,0.0005445157,0.004420136,0.0004138266,0.5196594,0.4622758,0.0001153392],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.00311212,0.270938,0.09400078,0.5042855,0.007659452,0.001656792,0.0004647217,0.0003101279,0.1175725],"genre_scores_gemma":[0.2030042,0.3698698,0.1682694,0.1978792,0.03236035,0.005816321,0.000837869,0.000428061,0.02153481],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.1484461,"threshold_uncertainty_score":0.7850674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4991860786520705,"score_gpt":0.592009268955778,"score_spread":0.09282319030370745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}