{"id":"W2945141847","doi":"10.1371/journal.pgen.1008157","title":"Genetic analyses led to the discovery of a super-active mutant of the RNA polymerase I","year":2019,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Université de Toulouse; Ministerio de Economía y Competitividad; Ministry of Economy, Trade and Industry; Agence Nationale de la Recherche","keywords":"Biology; RNA polymerase III; RNA polymerase II; RNA polymerase I; Genetics; Processivity; Transcription (linguistics); RNA polymerase; Mutant; Polymerase; DNA polymerase; RNA; Molecular biology; Gene; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007183243,0.0001195992,0.0001729488,0.00003482935,0.00004522899,0.00001526548,0.0004575756,0.00005922127,0.00001948076],"category_scores_gemma":[0.00009015058,0.00006841043,0.0001396898,0.0001871125,0.00009278291,0.000002382823,0.0002697425,0.0000774038,0.000006694066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009011384,"about_ca_system_score_gemma":0.000125646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005471703,"about_ca_topic_score_gemma":0.00005899563,"domain_scores_codex":[0.9989546,0.00009900403,0.0002206944,0.0002155658,0.0002845127,0.0002256188],"domain_scores_gemma":[0.9990029,0.00002883859,0.00008447467,0.0007192316,0.0001072982,0.00005725292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009095419,0.00006774353,0.005503458,0.00002270672,0.0001347218,7.6576e-7,0.0001075861,0.0008712197,0.9925085,0.000008773177,0.00006379912,0.0006197852],"study_design_scores_gemma":[0.0002338392,0.0002962505,0.009941499,0.00002205255,0.00004084749,0.000002245766,0.0002485655,0.0009370891,0.9879919,0.00001101323,0.0001881764,0.00008656897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978603,0.0009990974,0.0001414228,0.0001953599,0.0000547521,0.000391539,0.00006619704,0.000001784902,0.000289505],"genre_scores_gemma":[0.9987901,0.0001450401,0.0001235616,0.0001667939,0.0000729244,0.00001251768,0.000005559945,0.00001752369,0.0006659846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004516634,"threshold_uncertainty_score":0.2789696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141985765308474,"score_gpt":0.2915418974927809,"score_spread":0.2701220398396961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}