{"id":"W2945156377","doi":"10.3389/fpsyt.2019.00345","title":"Individualized Prediction of Transition to Psychosis in 1,676 Individuals at Clinical High Risk: Development and Validation of a Multivariable Prediction Model Based on Individual Patient Data Meta-Analysis","year":2019,"lang":"en","type":"review","venue":"Frontiers in Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Hotchkiss Brain Institute; University of Calgary","funders":"Universität zu Köln; Japan Society for the Promotion of Science; National Health and Medical Research Council; National Research Foundation of Korea; Medical Research Council; GGZ Drenthe; National Research Foundation; University of Tokyo; National Alliance for Research on Schizophrenia and Depression; ZonMw; Rijksuniversiteit Groningen; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; GGZ Friesland; King's College London; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Japan Agency for Medical Research and Development; South London and Maudsley NHS Foundation Trust; National Science Foundation; Stanley Medical Research Institute; Ministry of Education, Culture, Sports, Science and Technology; National Institute of Mental Health; Fondation pour la Recherche Médicale; Brain and Behavior Research Foundation","keywords":"Multivariable calculus; Meta-analysis; Psychosis; Patient data; Psychology; Medicine; Clinical psychology; Computer science; Psychiatry; Internal medicine; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04179519,0.00206675,0.009589691,0.005111748,0.0005631697,0.002940655,0.002912803,0.001873494,0.002426041],"category_scores_gemma":[0.06235036,0.001157768,0.03808153,0.005077189,0.0004463705,0.001650153,0.001839578,0.002366682,0.0003359122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001008692,"about_ca_system_score_gemma":0.001791693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004185975,"about_ca_topic_score_gemma":0.004435683,"domain_scores_codex":[0.9794208,0.01459514,0.002611506,0.002136568,0.0009841686,0.0002518736],"domain_scores_gemma":[0.9554757,0.03923184,0.002107101,0.001807216,0.0011343,0.0002437688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006833698,0.0001014628,0.0615027,0.03269466,0.8651496,0.0002427459,0.0001689903,0.0105949,0.0003339253,0.000452185,0.001042395,0.02088281],"study_design_scores_gemma":[0.001299213,0.0005532209,0.01528945,0.002287681,0.9640191,0.0001429055,0.00006046293,0.01333751,0.0002175988,0.001426467,0.001309261,0.00005717907],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1944091,0.7056383,0.07903101,0.002735242,0.0009091374,0.002268681,0.01213545,0.000767709,0.002105363],"genre_scores_gemma":[0.9159139,0.05022605,0.02601365,0.0006471075,0.000213452,0.002263606,0.004131265,0.0001207605,0.0004702266],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.04179519,"threshold_uncertainty_score":0.2210367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1464935188077477,"score_gpt":0.3883473830053801,"score_spread":0.2418538641976324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}