{"id":"W2945207184","doi":"10.1101/645929","title":"The kynurenine pathway is essential for rhodoquinone biosynthesis in <i>Caenorhabditis elegans</i>","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Dalhousie University; Agencia Nacional de Investigación e Innovación; Institut Pasteur de Montevideo; Dr. Scholl Foundation","keywords":"Biosynthesis; Biology; Kynurenine pathway; Caenorhabditis elegans; Biochemistry; Mutant; Metabolic pathway; Enzyme; Gene; Kynurenine; Tryptophan; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007210023,0.000622787,0.0005936841,0.0001053943,0.000287133,0.0001843155,0.0007357548,0.0006703493,0.00001193464],"category_scores_gemma":[0.0003388173,0.000548307,0.0003539851,0.000232375,0.0001581715,0.000007313578,0.0008162262,0.0004160166,0.00002616457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008911734,"about_ca_system_score_gemma":0.0004229928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000676538,"about_ca_topic_score_gemma":0.00005757473,"domain_scores_codex":[0.9970314,0.0001368555,0.0005378472,0.001198175,0.0002705406,0.0008252072],"domain_scores_gemma":[0.997508,0.000144498,0.0003399659,0.001528125,0.0003375661,0.0001418094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001916582,0.0001050412,0.001160882,0.0002921591,0.0002708485,0.00001087865,0.000007664524,0.00003487015,0.9539441,0.0001056068,0.04386549,0.00001081579],"study_design_scores_gemma":[0.0007595876,0.0001712294,0.004976763,0.0001693149,0.00007134389,2.42814e-8,0.000004431792,0.000111596,0.7826254,0.000001453071,0.2104656,0.0006432803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803199,0.01037493,0.001751941,0.001609896,0.002725036,0.00205124,0.001070707,0.00007942448,0.00001699374],"genre_scores_gemma":[0.994118,0.002500028,0.0007119719,0.0004145074,0.001418426,0.0005966179,0.000003260708,0.0001550658,0.00008214769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1713187,"threshold_uncertainty_score":0.9996969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006449508914199678,"score_gpt":0.2105990154088068,"score_spread":0.2041495064946071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}