{"id":"W2945308791","doi":"10.1093/nar/gkz441","title":"Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex","year":2019,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Medical Research Council; Medical Research Council Canada; University of Aberdeen; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; American Cancer Society; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Proliferating cell nuclear antigen; DNA mismatch repair; Biology; DNA replication; Replication factor C; DNA repair; DNA polymerase delta; DNA clamp; DNA; Molecular biology; Genetics; Cell biology; Eukaryotic DNA replication; Gene; Reverse transcriptase; Polymerase chain reaction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236093,0.0004698815,0.0002576858,0.000196878,0.0001652029,0.0004167773,0.0002941046,0.0003738822,0.001268706],"category_scores_gemma":[0.0001945998,0.0002203919,0.0002275268,0.000100984,0.0002513602,0.000283901,0.0006705368,0.000513869,0.0008138256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005526972,"about_ca_system_score_gemma":0.0002149396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006108813,"about_ca_topic_score_gemma":0.0007266267,"domain_scores_codex":[0.9997701,0.00002104279,0.00002179208,0.00007964683,0.00005935089,0.00004800472],"domain_scores_gemma":[0.9997912,0.00002497426,0.00007873979,0.0000354022,0.00002168701,0.00004792376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000349837,0.000007186419,0.0001983703,0.00001646006,0.00000238085,0.00002232569,0.000005247903,0.0000488334,0.9988891,0.00005311337,0.00002020192,0.0007016356],"study_design_scores_gemma":[0.000005014714,0.00004013866,0.003480145,0.000003662072,0.000004357416,0.0001185014,0.00001028299,0.0007356672,0.9944047,0.0000469405,0.001146144,0.000004501991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923393,0.001389046,0.004579561,0.0001238524,0.0000302879,0.00001655953,0.0002465059,0.0002646732,0.001010204],"genre_scores_gemma":[0.9956584,0.000281373,0.001719178,0.00005276818,0.000004059781,0.00001464395,0.0003536534,0.00007192182,0.001843944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001268706,"threshold_uncertainty_score":0.004244268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04407911212100328,"score_gpt":0.3470868729528354,"score_spread":0.3030077608318321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}