{"id":"W2945317060","doi":"10.1161/jaha.118.011306","title":"New Strategies for the Conduct of Clinical Trials in Pediatric Pulmonary Arterial Hypertension: Outcome of a Multistakeholder Meeting With Patients, Academia, Industry, and Regulators, Held at the European Medicines Agency on Monday, June 12, 2017","year":2019,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; Feinberg School of Medicine; National Heart, Lung, and Blood Institute; Northwestern University; Hospital for Sick Children; Tokyo Medical and Dental University; Vrije Universiteit Brussel; Warszawski Uniwersytet Medyczny; Deutsche Herzstiftung; Uniwersytet Warszawski; European Federation of Pharmaceutical Industries and Associations; University College London; Imperial College London; European Commission; Ottawa Hospital Research Institute; Università di Bologna","keywords":"Medicine; Food and drug administration; Agency (philosophy); Clinical trial; Pulmonary hypertension; Family medicine; Internal medicine; Sociology; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.7586527,0.003132621,0.003248666,0.003965041,0.005861945,0.02540695,0.006889686,0.01823905,0.01310864],"category_scores_gemma":[0.556027,0.002505087,0.005549104,0.003427908,0.009291226,0.02148004,0.02085769,0.0267141,0.006229053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01487749,"about_ca_system_score_gemma":0.082399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001765951,"about_ca_topic_score_gemma":0.003942295,"domain_scores_codex":[0.2455589,0.6900147,0.02825765,0.006208281,0.02475437,0.005206082],"domain_scores_gemma":[0.2665659,0.4472993,0.0609144,0.05309927,0.1215416,0.05057951],"domain_codex":"methods","domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006980502,0.002529311,0.007015365,0.02739154,0.00181794,0.001290276,0.01373819,0.003931604,0.006413627,0.04652378,0.2446773,0.6376906],"study_design_scores_gemma":[0.00779612,0.008335631,0.01535836,0.04467219,0.001359931,0.0009216466,0.00896898,0.005191449,0.003823647,0.06675035,0.8360922,0.000729425],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.007810907,0.07025432,0.1284012,0.7118579,0.02078485,0.04137342,0.001022201,0.000887025,0.01760811],"genre_scores_gemma":[0.0778773,0.03099812,0.6341186,0.1616615,0.01203367,0.07598731,0.0009719886,0.0005923229,0.00575918],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.7586527,"threshold_uncertainty_score":0.2976242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1630821156746468,"score_gpt":0.4053320772418403,"score_spread":0.2422499615671934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}