{"id":"W2945356552","doi":"10.1016/j.bja.2019.04.047","title":"Propofol pharmacokinetic model and lean body weight scalar for dose estimation in morbid obesity","year":2019,"lang":"en","type":"letter","venue":"British Journal of Anaesthesia","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Manitoba Beekeepers' Association","funders":"","keywords":"Propofol; NONMEM; Medicine; Pharmacokinetics; Dosing; Population; Sedation; Obesity; Pharmacodynamics; Body weight; Anesthesia; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007864577,0.0003004307,0.0006849755,0.000304122,0.0001706533,0.0007909046,0.0003842672,0.00156114,0.0008710034],"category_scores_gemma":[0.009792658,0.0002277949,0.0004692705,0.0002356758,0.0002518242,0.0006236631,0.0003209849,0.002534383,0.000837795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006471148,"about_ca_system_score_gemma":0.0004765542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002496912,"about_ca_topic_score_gemma":0.001890033,"domain_scores_codex":[0.9996153,0.00019213,0.00004025459,0.00003366028,0.00009845474,0.0000201227],"domain_scores_gemma":[0.9973436,0.001913154,0.0001651415,0.0001280415,0.0003709257,0.000079184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.005706859,0.0005602526,0.05074809,0.0006041471,0.0003809567,0.02898285,0.0007918578,0.1877116,0.01820882,0.02118421,0.1746991,0.5104213],"study_design_scores_gemma":[0.0003569867,0.0007469447,0.01024274,0.0002554193,0.0001554896,0.02031264,0.0001738176,0.8811622,0.00795617,0.02573,0.05279179,0.000115755],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2332974,0.01520089,0.4529241,0.2638543,0.008926338,0.0001557867,0.001031002,0.001658348,0.02295182],"genre_scores_gemma":[0.9084345,0.004353012,0.06463574,0.01125605,0.002920986,0.0001149398,0.0002504245,0.0002570932,0.007777087],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002496912,"threshold_uncertainty_score":0.004964709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813162398217992,"score_gpt":0.2753285115372194,"score_spread":0.2571968875550394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}