{"id":"W2945366030","doi":"10.1128/mbio.00826-19","title":"Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of <i>Paramyxoviridae</i> and <i>Pneumoviridae</i>","year":2019,"lang":"en","type":"article","venue":"mBio","topic":"Respiratory viral infections research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Independent Electricity System Operator; National Medical Research Council; Canada Foundation for Innovation; Deutsches Zentrum für Infektionsforschung; Washington State Department of Natural Resources; University of Washington","keywords":"Translation (biology); Host (biology); Function (biology); Virology; Biology; Cell biology; Messenger RNA; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000301382,0.0001766155,0.0004771064,0.0002065515,0.00007727091,0.00002196362,0.00007798111,0.0001407553,0.0001686637],"category_scores_gemma":[0.00003360148,0.0001606915,0.0001255505,0.0002870203,0.00022282,0.0001544152,0.00002343568,0.0001905236,0.00004435565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000415443,"about_ca_system_score_gemma":0.0001177731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001261359,"about_ca_topic_score_gemma":0.00001757489,"domain_scores_codex":[0.9984384,0.0001053584,0.0004411832,0.0003649647,0.0004056079,0.0002444955],"domain_scores_gemma":[0.9988754,0.0001348175,0.0001686028,0.0003540623,0.000324515,0.0001425625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001700741,0.0003821154,0.01272394,0.0003080221,0.00008520675,0.000002170986,0.0004224443,0.0001682877,0.9828511,0.0003146868,0.00008240751,0.0009588129],"study_design_scores_gemma":[0.004287711,0.005718335,0.05655697,0.0001210047,0.0001556352,0.00001552976,0.0002244036,0.005000412,0.9241331,0.00005541515,0.003489819,0.000241679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924537,0.0002228314,0.003999235,0.00008503693,0.0001695718,0.001683763,0.0001250677,0.00003183294,0.001228967],"genre_scores_gemma":[0.999139,0.000008909135,0.0003180549,0.00006717159,0.00009709358,0.00002736522,0.00006928272,0.0000241657,0.0002489461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05871809,"threshold_uncertainty_score":0.6552809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04682782728430778,"score_gpt":0.3486438602423235,"score_spread":0.3018160329580157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}