{"id":"W2945389058","doi":"10.1038/s41467-019-09900-9","title":"Schistosoma mansoni treatment reduces HIV entry into cervical CD4+ T cells and induces IFN-I pathways","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health; Canada Research Chairs; University of Manitoba; University Health Network; University of Toronto; SickKids Foundation; Public Health Ontario; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Fogarty International Center; National Institutes of Health","keywords":"Schistosoma mansoni; Immunology; Schistosomiasis; Peripheral blood mononuclear cell; Immune system; Ex vivo; Schistosoma; Schistosoma japonicum; Transcriptome; Medicine; Interferon; Biology; In vivo; In vitro; Helminths; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000605974,0.0001582801,0.000171188,0.000122029,0.0001153986,0.000149627,0.00006768881,0.0001199229,0.001971847],"category_scores_gemma":[0.0000997149,0.00006562609,0.0001032247,0.00007552217,0.0001399162,0.0000653442,0.0001203138,0.000288426,0.0001963335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001127517,"about_ca_system_score_gemma":0.0001378902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004115639,"about_ca_topic_score_gemma":0.0009779857,"domain_scores_codex":[0.9999415,0.00001472381,0.000003683836,0.000007576681,0.00001132185,0.00002126684],"domain_scores_gemma":[0.9999646,0.000006302045,0.00001167245,0.000003632788,0.000004124285,0.000009597575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007575282,0.00008938207,0.002479153,0.0001501545,0.00001039911,0.00005286357,0.00003564801,0.00009383682,0.98367,0.00004345868,0.0001366641,0.01248087],"study_design_scores_gemma":[0.0001247128,0.00680326,0.1103324,0.00006722947,0.00006435302,0.0005907295,0.0003175042,0.001081289,0.870841,0.0001564583,0.009612428,0.000008704676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964239,0.00171388,0.000298787,0.00009920318,0.00001722667,0.00002272858,0.000236139,0.00002540145,0.001162798],"genre_scores_gemma":[0.996731,0.000892401,0.0004514503,0.0000544071,0.00001062106,0.00003339687,0.0002465413,0.000004604676,0.00157566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001971847,"threshold_uncertainty_score":0.006596446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536097452202622,"score_gpt":0.2881360448956721,"score_spread":0.2727750703736458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}