{"id":"W2945420944","doi":"10.3389/fncel.2019.00209","title":"Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease","year":2019,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Teva Pharmaceutical Industries","keywords":"Neuroscience; Huntington's disease; Neuroplasticity; Homeostatic plasticity; Disease; Homeostasis; Plasticity; Biology; Psychology; Medicine; Synaptic plasticity; Pathology; Cell biology; Genetics; Receptor; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001787967,0.0006854094,0.0005515045,0.000577962,0.0002794536,0.0004031274,0.0005905309,0.0005865383,0.001354782],"category_scores_gemma":[0.0001513779,0.0003553183,0.0005547334,0.0003813201,0.0003387079,0.0002616407,0.0002795332,0.001558749,0.0008517936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004615753,"about_ca_system_score_gemma":0.0003625681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002193503,"about_ca_topic_score_gemma":0.00402662,"domain_scores_codex":[0.9996632,0.00002130095,0.0000550296,0.0000913097,0.0001070505,0.00006210637],"domain_scores_gemma":[0.9997256,0.00003170249,0.00006507056,0.00004967517,0.00003615066,0.00009173962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005454178,0.00002889816,0.00009410351,0.00002312292,0.000008817738,0.0001134468,0.00001970655,0.00003238231,0.9991203,0.00003315912,0.00004138472,0.0004300936],"study_design_scores_gemma":[0.00003122562,0.0003615464,0.008861121,0.00001376279,0.00004591204,0.0005852265,0.00006712669,0.001188664,0.9865246,0.00009798288,0.002211582,0.00001125527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861842,0.002150989,0.004433907,0.0002946623,0.0001595469,0.00008050772,0.0037316,0.000302053,0.002662508],"genre_scores_gemma":[0.9762096,0.001990545,0.005965156,0.0001572849,0.00002636732,0.0003494643,0.003755196,0.0001182162,0.0114282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002193503,"threshold_uncertainty_score":0.004532218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872980250670151,"score_gpt":0.2328698358430089,"score_spread":0.2141400333363074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}