{"id":"W2945467118","doi":"10.7554/elife.44530","title":"A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction","year":2019,"lang":"en","type":"article","venue":"eLife","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":275,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; St. Michael's Hospital; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University of New Brunswick","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Research Chairs; Canada First Research Excellence Fund; National Institutes of Health; U.S. Environmental Protection Agency; Ontario Institute for Regenerative Medicine; AFM-Téléthon; Burroughs Wellcome Fund; University of Toronto; Canada Foundation for Innovation; Krembil Foundation","keywords":"Neuromuscular junction; Acetylcholine receptor; Motor neuron; Neuroscience; Myasthenia gravis; Myocyte; Biology; Induced pluripotent stem cell; Skeletal muscle; Motor Endplate; Myogenesis; Calcium imaging; Anatomy; Cell biology; Embryonic stem cell; Receptor; Medicine; Calcium; Immunology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007968953,0.0001216306,0.0001864291,0.00005091495,0.0001011847,0.000009414784,0.0003026556,0.00003631959,0.000004454567],"category_scores_gemma":[0.000399337,0.00007770219,0.0000977413,0.0004345844,0.0001373225,0.0002080803,0.0001347528,0.0001486014,0.000006058029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000104532,"about_ca_system_score_gemma":0.00001668479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009026889,"about_ca_topic_score_gemma":0.000002165875,"domain_scores_codex":[0.9988535,0.00005060219,0.000230099,0.0002729624,0.0004148672,0.0001779472],"domain_scores_gemma":[0.9994003,0.00003537787,0.0001246588,0.0003185158,0.00009312526,0.00002799901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000002477761,0.00003059593,0.000118879,0.00005680318,0.000002120769,8.589467e-7,0.0002944606,0.01220981,0.9863532,0.0007381132,0.0001099424,0.00008277634],"study_design_scores_gemma":[0.0002171359,0.0001061821,0.001380439,0.00004654732,0.000009825821,0.000002501012,0.00007268864,0.03151886,0.9661318,0.00005249962,0.0003707342,0.00009079534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989519,0.00003982606,0.00002487663,0.00008331294,0.0003997386,0.0001936772,0.000005530615,0.0000431668,0.0002580251],"genre_scores_gemma":[0.9985164,0.00009240149,0.00002954701,0.0005141648,0.00002285511,0.000006038453,3.047431e-7,0.00001289272,0.0008053876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02022137,"threshold_uncertainty_score":0.3168603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04490032560819726,"score_gpt":0.2728828141027069,"score_spread":0.2279824884945096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}