{"id":"W2945633067","doi":"10.1371/journal.pone.0216423","title":"The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC; National Science Foundation","keywords":"Mefloquine; Nonsense mutation; Stop codon; Biology; Aminoglycoside; Molecular biology; Mutation; Gene; Cell biology; Cancer research; Genetics; Chloroquine; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001159942,0.0002882484,0.0002384146,0.0001503588,0.00006192843,0.0001401587,0.0001191643,0.0001741701,0.0009429991],"category_scores_gemma":[0.0001163141,0.00009408164,0.000207219,0.00008667965,0.0000909394,0.000124413,0.000125532,0.0002794181,0.0002032162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001215137,"about_ca_system_score_gemma":0.00008866684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003819526,"about_ca_topic_score_gemma":0.0006054077,"domain_scores_codex":[0.9998794,0.00003565196,0.00001290262,0.00001676952,0.00003227965,0.00002306309],"domain_scores_gemma":[0.9999114,0.00002905598,0.00002234626,0.00001017434,0.00001338398,0.00001374695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006126478,0.00002162203,0.00008293537,0.00001782077,0.000002105506,0.00002103883,0.000004599225,0.00003443966,0.998773,0.00001326561,0.00001368549,0.0009540719],"study_design_scores_gemma":[0.00001332286,0.0008290113,0.002792635,0.000004236257,0.000006696838,0.0001336743,0.000006780187,0.0003400656,0.9948991,0.000009073351,0.0009632188,0.000002368343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963827,0.001260604,0.001058119,0.00004758117,0.000013057,0.00002775036,0.0001434811,0.00006355919,0.001003166],"genre_scores_gemma":[0.9966894,0.0006756996,0.001136029,0.00002998609,0.000006379252,0.00001401894,0.0002626517,0.00001176189,0.001174061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009429991,"threshold_uncertainty_score":0.003154695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164505781362057,"score_gpt":0.2248792335229323,"score_spread":0.2132341757093117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}