{"id":"W2945633067","doi":"10.1371/journal.pone.0216423","title":"The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC; National Science Foundation","keywords":"Mefloquine; Nonsense mutation; Stop codon; Biology; Aminoglycoside; Molecular biology; Mutation; Gene; Cell biology; Cancer research; Genetics; Chloroquine; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002843041,0.0002168077,0.000390206,0.00005405234,0.0001299993,0.00005412933,0.0001857877,0.0001865535,0.0001581297],"category_scores_gemma":[0.0002348941,0.0001625099,0.00009521775,0.0002191199,0.00009431289,0.0001435199,0.0000653211,0.0004515749,0.0002951332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001343623,"about_ca_system_score_gemma":0.00009224299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000535781,"about_ca_topic_score_gemma":0.00003765698,"domain_scores_codex":[0.9980637,0.00007803788,0.0003317643,0.0003993079,0.000777721,0.0003494879],"domain_scores_gemma":[0.9987609,0.0001302917,0.0001888207,0.0006392769,0.0001868364,0.00009390971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004212426,0.0006106505,0.0004224725,0.0001955663,0.0002926591,0.00001703414,0.0003733615,0.000001506159,0.9842384,0.0001367536,0.01199782,0.001292516],"study_design_scores_gemma":[0.002067528,0.0004526786,0.001340179,0.0008167183,0.00045383,0.00001928459,0.00007314129,0.0005261658,0.9848847,0.00009166167,0.009054995,0.0002190884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841512,0.002541267,0.00005694362,0.003929245,0.0004223924,0.001420181,0.00003919337,0.0001547071,0.007284825],"genre_scores_gemma":[0.9855099,0.0007226744,0.001049857,0.0003960816,0.0004190969,0.00006606786,0.0001844225,0.00005855245,0.01159332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004308494,"threshold_uncertainty_score":0.6626961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164505781362057,"score_gpt":0.2248792335229323,"score_spread":0.2132341757093117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}