{"id":"W2945659966","doi":"10.1021/acsnano.8b09679","title":"Delivery of MicroRNAs by Chitosan Nanoparticles to Functionally Alter Macrophage Cholesterol Efflux <i>in Vitro</i> and <i>in Vivo</i>","year":2019,"lang":"en","type":"article","venue":"ACS Nano","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"In vivo; microRNA; ABCA1; Cholesterol; Efflux; Chitosan; In vitro; Cell biology; Macrophage; Gene delivery; Intracellular; Chemistry; Transfection; Biology; Biochemistry; Gene; Transporter; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825796,0.0004625978,0.0001517853,0.0001268824,0.0001005368,0.0001956926,0.000188505,0.000407712,0.000631669],"category_scores_gemma":[0.0001374148,0.0001591011,0.0002958902,0.0001021953,0.0002438219,0.0001935399,0.0001146919,0.0003753087,0.0001744701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004528847,"about_ca_system_score_gemma":0.0003096921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001544234,"about_ca_topic_score_gemma":0.001551129,"domain_scores_codex":[0.9998831,0.00001653304,0.00001107108,0.0000266602,0.00003178801,0.00003086953],"domain_scores_gemma":[0.9999157,0.00001583874,0.0000289407,0.000006709553,0.00002077887,0.00001205863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000431724,0.00001161622,0.00002726242,0.00002572823,0.000002786714,0.00001273926,0.000003959653,0.00006005612,0.9992974,0.00004870055,0.00002514535,0.0004415148],"study_design_scores_gemma":[0.00001052719,0.0001378317,0.0002927567,0.000001937899,0.000008198325,0.00003034386,0.000003208499,0.0004965911,0.9984074,0.00001044773,0.000597611,0.000003147768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849015,0.001694838,0.01016486,0.0002367823,0.00008342025,0.0001196195,0.0002377596,0.0001500681,0.002411118],"genre_scores_gemma":[0.9854215,0.0009555878,0.01011432,0.000188745,0.00001713641,0.00009824504,0.0002251109,0.0000433107,0.002935942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001544234,"threshold_uncertainty_score":0.003285944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003019408310319789,"score_gpt":0.1994930354899598,"score_spread":0.19647362717964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}