{"id":"W2945700112","doi":"10.1038/s41467-019-10152-w","title":"Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University","funders":"Pfizer Canada; Studienstiftung des Deutschen Volkes; Deutsche Forschungsgemeinschaft; Government of Canada; Faculty of Medicine, McGill University; McGill University; Velux Stiftung; Consortium canadien en neurodégénérescence associée au vieillissement; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Neurodegeneration; Dementia; Cerebrospinal fluid; Cohort; Disease; Amyloid precursor protein; Alzheimer's disease; Medicine; Amyloid (mycology); Amyloid beta; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005428303,0.0005460472,0.0003560625,0.001927991,0.0003598445,0.0008062118,0.0002087302,0.0005573611,0.00140526],"category_scores_gemma":[0.001151006,0.0002669771,0.0002955376,0.0006478062,0.0003658944,0.0003884519,0.0004203358,0.0004886856,0.0004030506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000276279,"about_ca_system_score_gemma":0.0002307875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001237932,"about_ca_topic_score_gemma":0.0007206238,"domain_scores_codex":[0.9996058,0.0001100451,0.00004111789,0.00008800112,0.0001072119,0.00004782139],"domain_scores_gemma":[0.9994869,0.00004898786,0.0002840135,0.00003085674,0.00007765918,0.00007142055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00278645,0.0002960079,0.1904537,0.0002274916,0.0003239756,0.002797744,0.0004769757,0.0002565778,0.7695265,0.0006275296,0.0008821927,0.03134492],"study_design_scores_gemma":[0.00006180397,0.001087912,0.8435045,0.00007034661,0.000166195,0.01250451,0.0002206419,0.0007436396,0.1344087,0.001666201,0.005519637,0.00004594905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904394,0.006185377,0.001134688,0.0001473388,0.00002897904,0.00002704954,0.0002809368,0.00005293149,0.001703264],"genre_scores_gemma":[0.9957521,0.001512188,0.001531549,0.00004975188,0.00002662493,0.00001543586,0.0002780468,0.0000121969,0.0008221459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001927991,"threshold_uncertainty_score":0.004701078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02937332211645059,"score_gpt":0.3463263003200072,"score_spread":0.3169529782035566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}