{"id":"W2945780887","doi":"10.3727/096504019x15579146061957","title":"Profilin 2 Promotes Proliferation and Metastasis of Head and Neck Cancer Cells by Regulating PI3K/AKT/β-Catenin Signaling Pathway","year":2019,"lang":"en","type":"article","venue":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Protein kinase B; Downregulation and upregulation; Gene knockdown; Cancer research; PI3K/AKT/mTOR pathway; Metastasis; Cell growth; Catenin; Biology; Signal transduction; Cancer; Cell culture; Wnt signaling pathway; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002183382,0.0001870089,0.0004703487,0.00004829596,0.0001648713,0.00005020709,0.0001481213,0.0004741362,0.00004339466],"category_scores_gemma":[0.0002097702,0.0001550962,0.00009364423,0.000122275,0.0003604521,0.00001684802,0.0002944407,0.0007656393,0.000001507754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002865728,"about_ca_system_score_gemma":0.0002999878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000945679,"about_ca_topic_score_gemma":0.0001574128,"domain_scores_codex":[0.9973747,0.0006433284,0.0006874984,0.0006898002,0.0002302899,0.0003744071],"domain_scores_gemma":[0.9983621,0.0006212218,0.0002326665,0.0002481543,0.0003528296,0.0001830325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009733263,0.0003672687,0.03842421,0.0001515646,0.0003625574,0.000001058024,0.0001051929,0.000009258309,0.8396711,0.00008784186,0.0001298932,0.1197168],"study_design_scores_gemma":[0.003007083,0.006375747,0.004567831,0.000257634,0.0001588786,0.00001043908,0.0001907813,0.00192162,0.9485481,0.0005307097,0.03406132,0.000369821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885258,0.008845445,0.00004683122,0.001475375,0.0002524088,0.0006632525,0.00006438392,0.000009482592,0.0001170371],"genre_scores_gemma":[0.9854376,0.01178224,0.001082474,0.0002638292,0.0002619134,0.00009374502,0.00003356328,0.00003028635,0.001014372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1193469,"threshold_uncertainty_score":0.6324639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1209927072582436,"score_gpt":0.4556264656787377,"score_spread":0.3346337584204941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}