{"id":"W2945787812","doi":"10.1093/intbio/zyz008","title":"Microfluidic platform for studying osteocyte mechanoregulation of breast cancer bone metastasis","year":2019,"lang":"en","type":"article","venue":"Integrative Biology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Extravasation; Osteocyte; Breast cancer; Cancer cell; Bone metastasis; Metastasis; Cancer; Chemistry; Bone cell; Mechanotransduction; Pathology; Medicine; Cancer research; Cell biology; Internal medicine; In vitro; Biology; Osteoblast","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445478,0.0001498998,0.0002428992,0.0000773366,0.00004349412,0.000006668915,0.0001114138,0.0001395107,0.0001618731],"category_scores_gemma":[0.0000259665,0.0001159057,0.0001619847,0.0000737133,0.00003789327,0.000006535111,0.00006133722,0.00006636104,0.000006957767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003067623,"about_ca_system_score_gemma":0.00006245188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001040021,"about_ca_topic_score_gemma":0.00008650605,"domain_scores_codex":[0.999203,0.00003713737,0.0002484507,0.0002951983,0.00004223852,0.0001740108],"domain_scores_gemma":[0.9992889,0.00003006826,0.00016765,0.000203538,0.0002785813,0.00003127627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002564685,0.00004473847,0.0004881742,0.00001330923,0.0001705134,1.561783e-7,0.00005728782,0.000002071945,0.9876126,0.003349174,0.0005004989,0.007505008],"study_design_scores_gemma":[0.0005983186,0.0006145472,0.0003925012,0.00002505778,0.00004142519,0.0000191435,0.0004524544,0.0001679123,0.9726401,0.0006272515,0.02427682,0.0001444436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743061,0.002946511,0.02074931,0.0001450047,0.0005585116,0.0005090618,0.0006100755,0.000007130292,0.0001683105],"genre_scores_gemma":[0.9977788,0.0006258751,0.0004262641,0.00008365321,0.0001037863,0.00009251019,0.0004050019,0.00001733938,0.0004667913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02377633,"threshold_uncertainty_score":0.4726496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807667263732683,"score_gpt":0.2913171856812721,"score_spread":0.2732405130439453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}