{"id":"W2945787812","doi":"10.1093/intbio/zyz008","title":"Microfluidic platform for studying osteocyte mechanoregulation of breast cancer bone metastasis","year":2019,"lang":"en","type":"article","venue":"Integrative Biology","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Extravasation; Osteocyte; Breast cancer; Cancer cell; Bone metastasis; Metastasis; Cancer; Chemistry; Bone cell; Mechanotransduction; Pathology; Medicine; Cancer research; Cell biology; Internal medicine; In vitro; Biology; Osteoblast","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002011648,0.0003152562,0.000301982,0.0002087196,0.0001626467,0.0002397792,0.000280317,0.0003836252,0.0008149655],"category_scores_gemma":[0.0001365337,0.0001534893,0.0002065453,0.0001271223,0.0001400329,0.0001665387,0.0002484086,0.0003745065,0.0002102452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002993054,"about_ca_system_score_gemma":0.0003201325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005840431,"about_ca_topic_score_gemma":0.0006528971,"domain_scores_codex":[0.999872,0.00001420873,0.000007903389,0.00003971878,0.00003848153,0.00002774876],"domain_scores_gemma":[0.9999413,0.00001606016,0.00001429194,0.00000512835,0.00001079623,0.00001233578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002242567,0.00003056876,0.0001286285,0.00007782222,0.000004443182,0.00003888557,0.0000170232,0.0002996578,0.9957033,0.0004165327,0.000125442,0.003135338],"study_design_scores_gemma":[0.00003837824,0.0004763966,0.002747323,0.00002183738,0.00002712966,0.0001679225,0.00003187371,0.0140301,0.9721385,0.0002876258,0.01000916,0.00002384193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7923908,0.01078241,0.1859771,0.0006732687,0.0005203336,0.0004485463,0.001469807,0.001214061,0.006523755],"genre_scores_gemma":[0.8895199,0.003779431,0.1020147,0.0001630013,0.00005649247,0.000907806,0.0005177176,0.0000303023,0.003010699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008149655,"threshold_uncertainty_score":0.002726376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807667263732683,"score_gpt":0.2913171856812721,"score_spread":0.2732405130439453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}