{"id":"W2945815300","doi":"10.3762/bjoc.15.174","title":"Design, synthesis and biological evaluation of immunostimulating mannosylated desmuramyl peptides","year":2019,"lang":"en","type":"article","venue":"Beilstein Journal of Organic Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Medicinski Fakultet, Sveučilište u Zagrebu; Hrvatska Zaklada za Znanost; Terry Fox Foundation; Sveučilište u Zagrebu","keywords":"Muramyl dipeptide; Chemistry; Mannose; Adamantane; Peptidoglycan; Lipophilicity; Ovalbumin; Adjuvant; Peptide; Dipeptide; Mannose receptor; Biochemistry; Peptide synthesis; Lipopeptide; Linker; Immune system; Combinatorial chemistry; In vitro; Cell wall; Immunology; Organic chemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001768023,0.0001293724,0.0003334316,0.00005225099,0.00005347035,0.00001114711,0.0001581446,0.0002439275,0.00230204],"category_scores_gemma":[0.001093816,0.0001033887,0.00007544259,0.0001030593,0.00008569765,0.0001153975,0.00004769624,0.0002278958,0.00003441275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005701181,"about_ca_system_score_gemma":0.000164542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001524388,"about_ca_topic_score_gemma":4.415651e-8,"domain_scores_codex":[0.9987112,0.0003188937,0.0006077967,0.0001177564,0.00009246671,0.0001518393],"domain_scores_gemma":[0.9982389,0.0005592054,0.0006189144,0.0001592819,0.000408099,0.00001558588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003458308,0.00003840593,0.002572108,0.00003684067,0.0001890552,0.000001942121,0.0001694964,0.00007212076,0.9900435,0.000001866834,0.00001991102,0.006508972],"study_design_scores_gemma":[0.001280424,0.000143429,0.007245721,0.000207921,0.0001331847,0.0004435374,0.0003696884,0.0001011017,0.9898434,0.00006338782,0.00006095671,0.0001072254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947848,0.004569073,0.0001689706,0.00005032511,0.0001062971,0.0001301809,0.000001025521,0.000008989541,0.0001803057],"genre_scores_gemma":[0.9994674,0.0001458558,0.0001998439,0.000005202898,0.00001854379,0.000001574604,0.000006648643,0.00001041236,0.0001445155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006401747,"threshold_uncertainty_score":0.99861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02380655393910974,"score_gpt":0.245037503167099,"score_spread":0.2212309492279893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}