{"id":"W2945815300","doi":"10.3762/bjoc.15.174","title":"Design, synthesis and biological evaluation of immunostimulating mannosylated desmuramyl peptides","year":2019,"lang":"en","type":"article","venue":"Beilstein Journal of Organic Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Medicinski Fakultet, Sveučilište u Zagrebu; Hrvatska Zaklada za Znanost; Terry Fox Foundation; Sveučilište u Zagrebu","keywords":"Muramyl dipeptide; Chemistry; Mannose; Adamantane; Peptidoglycan; Lipophilicity; Ovalbumin; Adjuvant; Peptide; Dipeptide; Mannose receptor; Biochemistry; Peptide synthesis; Lipopeptide; Linker; Immune system; Combinatorial chemistry; In vitro; Cell wall; Immunology; Organic chemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001767005,0.0002999833,0.0002115587,0.0001319717,0.00007790119,0.000165657,0.0002186747,0.0002049336,0.0006235966],"category_scores_gemma":[0.0001214953,0.0001046331,0.0001947435,0.0001217482,0.0001273758,0.0001892493,0.0001286973,0.0002858093,0.0001797724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001915036,"about_ca_system_score_gemma":0.0001486668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001434492,"about_ca_topic_score_gemma":0.000219133,"domain_scores_codex":[0.9999225,0.00001706546,0.00000885596,0.00001286575,0.00002245105,0.00001636618],"domain_scores_gemma":[0.9999161,0.000009325677,0.00002849195,0.000005992639,0.00001747876,0.00002263713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001235523,0.00007198436,0.00006251367,0.00008128404,0.000006224931,0.00009793122,0.00001551315,0.0005753377,0.9954689,0.00008672569,0.00001862264,0.003391553],"study_design_scores_gemma":[0.0000559905,0.002494722,0.0006414205,0.000006518166,0.00001990853,0.0002127142,0.00001113074,0.0003854067,0.9932314,0.00002807502,0.002906895,0.000005844106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923251,0.002264033,0.003736765,0.00005422557,0.00002499785,0.0001586865,0.0002059603,0.00002285011,0.001207458],"genre_scores_gemma":[0.984342,0.003177926,0.009721956,0.00005340761,0.00001977699,0.00008260564,0.0004055153,0.00001018709,0.002186548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006235966,"threshold_uncertainty_score":0.002086103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02380655393910974,"score_gpt":0.245037503167099,"score_spread":0.2212309492279893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}