{"id":"W2945852816","doi":"10.1016/s1470-2045(19)30152-4","title":"Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":385,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"Celgene","keywords":"Pomalidomide; Lenalidomide; Dexamethasone; Bortezomib; Medicine; Refractory (planetary science); Multiple myeloma; Open label; Oncology; Internal medicine; Thalidomide; Randomized controlled trial; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001182864,0.0004328364,0.001790038,0.000124672,0.0002236687,0.00008014269,0.0003929042,0.0002199497,0.0002000064],"category_scores_gemma":[0.0009904037,0.0002053072,0.00007162076,0.0002572597,0.0003021592,0.0002227673,0.0001438824,0.0003995273,0.00003175916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002939396,"about_ca_system_score_gemma":0.0006554853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002095204,"about_ca_topic_score_gemma":0.0002730003,"domain_scores_codex":[0.9968541,0.0006150987,0.0005293651,0.0007091686,0.0003936116,0.0008986097],"domain_scores_gemma":[0.9950304,0.003007004,0.0004168356,0.0008520845,0.0003156048,0.0003780899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.938972,0.004497456,0.0242846,0.0001406316,0.001215255,0.0001806479,0.0002340704,0.00000256347,0.0006606058,0.00001741285,0.001443062,0.02835167],"study_design_scores_gemma":[0.9104992,0.06807929,0.005272681,0.0001814191,0.0006534564,0.0001021359,0.00008247628,0.0007664319,0.000390747,0.00001317452,0.01367968,0.0002793688],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779234,0.0002022655,0.00009616528,0.001030248,0.00009515249,0.01923356,0.0001390705,0.00008129615,0.001198846],"genre_scores_gemma":[0.9798231,0.0002544149,0.01249786,0.0007517229,0.0002994504,0.002732856,0.0003941474,0.000101689,0.003144834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06358183,"threshold_uncertainty_score":0.8372186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07880100858038529,"score_gpt":0.3826707602881763,"score_spread":0.303869751707791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}