{"id":"W2945852816","doi":"10.1016/s1470-2045(19)30152-4","title":"Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":385,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"Celgene","keywords":"Pomalidomide; Lenalidomide; Dexamethasone; Bortezomib; Medicine; Refractory (planetary science); Multiple myeloma; Open label; Oncology; Internal medicine; Thalidomide; Randomized controlled trial; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001833491,0.001781466,0.002795597,0.0004059583,0.0004369658,0.001382263,0.0009696438,0.001887615,0.006277301],"category_scores_gemma":[0.001530411,0.0006735656,0.002951838,0.0004718634,0.00132126,0.001209466,0.0006448421,0.003593403,0.0009329004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001174525,"about_ca_system_score_gemma":0.001278119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001527751,"about_ca_topic_score_gemma":0.003681336,"domain_scores_codex":[0.9993759,0.0003351516,0.00003162118,0.0001131662,0.0000420164,0.000102156],"domain_scores_gemma":[0.9992989,0.0002114087,0.000140241,0.00004787642,0.00002752509,0.0002740271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9792169,0.003182491,0.0005138399,0.0004674115,0.001085277,0.00003288553,0.0000550988,0.0003095558,0.001386098,0.0001162876,0.0008455428,0.0127887],"study_design_scores_gemma":[0.9766568,0.02142053,0.0008578377,0.0000237775,0.0002403321,0.00002112015,0.00001478372,0.0001480068,0.00008884243,0.0001363646,0.0003828766,0.000008723901],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799774,0.009331343,0.0005360901,0.001622258,0.0008395786,0.003315513,0.001442391,0.0001372124,0.002798216],"genre_scores_gemma":[0.983526,0.004263879,0.001690813,0.00215909,0.0005745372,0.002994618,0.001485738,0.00002702345,0.003278463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006277301,"threshold_uncertainty_score":0.02099961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07880100858038529,"score_gpt":0.3826707602881763,"score_spread":0.303869751707791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}