{"id":"W2945860133","doi":"10.1038/s41467-019-09893-5","title":"Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; European Foundation for the Study of Diabetes; Eli Lilly and Company; Crohn's and Colitis Foundation of Canada; Alberta Innovates; Centres de Recerca de Catalunya; Crohn's and Colitis Foundation; Generalitat de Catalunya; Diabetes Canada","keywords":"Autoimmune hepatitis; Immunology; Autoimmunity; Epitope; Major histocompatibility complex; T cell; Antigen; Liver disease; Biology; Autoimmune disease; Medicine; Immune system; Hepatitis; Antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346523,0.0003623712,0.0002390948,0.0001443749,0.0001095175,0.0001681564,0.0001284475,0.0002295367,0.0008981978],"category_scores_gemma":[0.00007532618,0.00008432975,0.0001520485,0.00005964331,0.0001850842,0.0001684837,0.0001710826,0.0003602107,0.0001746374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001002747,"about_ca_system_score_gemma":0.0000938782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005418091,"about_ca_topic_score_gemma":0.0001399635,"domain_scores_codex":[0.9999287,0.00001371484,0.000005084103,0.00002055122,0.00001611639,0.00001582023],"domain_scores_gemma":[0.999944,0.00001634195,0.00001673061,0.000007386301,0.000005161896,0.00001048842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006979701,0.0000424887,0.00007132163,0.00008535193,0.000005044197,0.00002319859,0.00000891417,0.0001827706,0.9927161,0.0001126134,0.00005494472,0.00662746],"study_design_scores_gemma":[0.00001712451,0.00102027,0.00050842,0.00000588279,0.00000907408,0.0002653585,0.000008058747,0.0005594562,0.9951545,0.0000672626,0.002382024,0.000002614117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701375,0.005161301,0.02012421,0.0002158179,0.00008742037,0.000109893,0.0001317315,0.0002515071,0.003780578],"genre_scores_gemma":[0.9902567,0.001506715,0.006717032,0.0001006785,0.00002683193,0.00006234781,0.00007531334,0.00001897226,0.0012355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008981978,"threshold_uncertainty_score":0.003004789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01714761488551864,"score_gpt":0.2822317875717416,"score_spread":0.2650841726862229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}