{"id":"W2945937650","doi":"10.1172/jci124012","title":"Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Children's Hospital; Hotchkiss Brain Institute","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Glycolysis; Multiple sclerosis; Metabolism; Medicine; Neuroscience; Immunology; Pathology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00220048,0.000130511,0.0006656183,0.0001615138,0.00003201928,0.00001055425,0.0001908575,0.0003127178,0.0003376734],"category_scores_gemma":[0.001681994,0.0001130162,0.000241033,0.000215528,0.0002592423,0.0003240403,0.00001843873,0.0006188193,0.00004408525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000314809,"about_ca_system_score_gemma":0.0002557097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000483314,"about_ca_topic_score_gemma":0.00003807658,"domain_scores_codex":[0.9968036,0.0005376316,0.002196726,0.0001721972,0.0001023201,0.0001875576],"domain_scores_gemma":[0.9964909,0.001478232,0.001570594,0.0001841511,0.0002426435,0.00003350849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002991433,0.00009617259,0.03012479,0.000046467,0.00008033309,0.000001515647,0.0007475587,0.0003469979,0.9601106,0.0001079348,0.0004172462,0.007621266],"study_design_scores_gemma":[0.003616075,0.0003455351,0.2180673,0.0003121681,0.0000526151,0.00001289683,0.000171273,0.0001004024,0.7761626,0.000443117,0.0006061823,0.0001098042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951573,0.001236001,0.0005069626,0.0006110866,0.002108163,0.0002296162,0.000004411246,0.000007699714,0.0001387837],"genre_scores_gemma":[0.9979559,0.000198881,0.001008122,0.0003903146,0.00008853412,0.000003413639,0.00001420198,0.00001375434,0.0003268305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1879425,"threshold_uncertainty_score":0.4608667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0544415034306928,"score_gpt":0.3161607105607375,"score_spread":0.2617192071300447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}