{"id":"W2946062650","doi":"10.1161/atvbaha.119.312537","title":"Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension","year":2019,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Heart, Lung, and Blood Institute; National Center for Advancing Translational Sciences; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Agence Nationale de la Recherche; Pfizer","keywords":"DNA damage; Apoptosis; Cancer research; Kinase; CHEK1; Pulmonary hypertension; Medicine; DNA repair; Protein kinase A; Downregulation and upregulation; Pulmonary artery; Biology; Cancer; Cell cycle; Pharmacology; Cell cycle checkpoint; Internal medicine; Cell biology; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048157,0.0004432457,0.0003046052,0.0002954671,0.0001668846,0.0001740471,0.0001909814,0.0003003499,0.001750603],"category_scores_gemma":[0.00009690126,0.00009150211,0.0002112038,0.0001309825,0.0002242029,0.0001635968,0.0001213794,0.0008649345,0.0002006932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002143645,"about_ca_system_score_gemma":0.0001832033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002278796,"about_ca_topic_score_gemma":0.0005544701,"domain_scores_codex":[0.999943,0.000008518104,0.00000461189,0.00001021519,0.00001081664,0.00002280478],"domain_scores_gemma":[0.9999635,0.000007239967,0.00001094669,0.000002956,0.000003267154,0.00001214128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002154897,0.000661802,0.0003005844,0.0002777849,0.00002851884,0.00009561388,0.0000212583,0.0002800263,0.9847643,0.0001561274,0.0002458186,0.01101324],"study_design_scores_gemma":[0.0007416437,0.01057549,0.008854087,0.00003776556,0.0001096831,0.0004887309,0.00003935237,0.001231774,0.9737486,0.00009025579,0.004071516,0.00001108005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912652,0.005775456,0.0009031706,0.000198962,0.0000999498,0.00006976536,0.0002584983,0.000117299,0.001311495],"genre_scores_gemma":[0.9955508,0.002420396,0.0006508561,0.00005843527,0.00002701549,0.00005885232,0.0002415846,0.000006378925,0.0009856172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001750603,"threshold_uncertainty_score":0.005856276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281114127618144,"score_gpt":0.2814174290720424,"score_spread":0.2486062877958609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}