{"id":"W2946078866","doi":"10.1016/j.ccell.2019.04.006","title":"Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":277,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis; Korea Institute of Toxicology; U.S. Department of Veterans Affairs","keywords":"PDGFRA; Kinase; Broad spectrum; Cancer research; Drug; Drug discovery; Biology; Pharmacology; Chemistry; Bioinformatics; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242331,0.0006160878,0.0005809385,0.0005474467,0.0002452509,0.0005797764,0.0006110345,0.0004194303,0.002768759],"category_scores_gemma":[0.0002018902,0.0001788251,0.0003415859,0.0005620032,0.0003111529,0.0002303136,0.0003045053,0.001326406,0.001737089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007484879,"about_ca_system_score_gemma":0.0005019043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009034,"about_ca_topic_score_gemma":0.002293839,"domain_scores_codex":[0.9997802,0.00002332841,0.00001704105,0.00003703595,0.00006917221,0.00007327044],"domain_scores_gemma":[0.999911,0.00001106467,0.00002074039,0.000009580353,0.00001220514,0.00003554953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003823949,0.0008013668,0.002937385,0.0005334375,0.0001736245,0.001679097,0.0000970113,0.002147988,0.7321556,0.002231442,0.01134659,0.2420725],"study_design_scores_gemma":[0.005000648,0.009024606,0.01316544,0.00008616514,0.000336919,0.01758263,0.0001201421,0.00367962,0.7279635,0.0006918887,0.2222354,0.0001131843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9220529,0.03170136,0.005699967,0.001457428,0.0003211299,0.0004940693,0.003979524,0.001518568,0.03277505],"genre_scores_gemma":[0.9708694,0.009603603,0.004352991,0.0004583983,0.00006129681,0.000188518,0.005019804,0.0001001826,0.009345721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002768759,"threshold_uncertainty_score":0.009262383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007928033327735338,"score_gpt":0.2575922429366754,"score_spread":0.2496642096089401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}