{"id":"W2946140124","doi":"10.5772/intechopen.86598","title":"Modulating the T Lymphocyte Immune Response via Secretome Produced miRNA: From Tolerance Induction to the Enhancement of the Anticancer Response","year":2019,"lang":"en","type":"book-chapter","venue":"IntechOpen eBooks","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of British Columbia","funders":"Canadian Institutes of Health Research; Health Canada; Centre for Blood Research, University of British Columbia; Michael Smith Health Research BC; University of British Columbia; Government of Canada; Canadian Blood Services; Australian Government","keywords":"Immunology; Immune system; Proinflammatory cytokine; Adoptive cell transfer; Cytotoxic T cell; Peripheral tolerance; Autoimmunity; T cell; Medicine; Cancer research; Biology; Inflammation; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006759875,0.0004249798,0.0002609203,0.0003982947,0.0001363846,0.0008761587,0.0002662854,0.0003698864,0.008380532],"category_scores_gemma":[0.00005245491,0.0001569882,0.0002217073,0.0004040932,0.0001917058,0.0007442481,0.0003456899,0.0009630673,0.00815596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002921358,"about_ca_system_score_gemma":0.0001528988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001175848,"about_ca_topic_score_gemma":0.0003213793,"domain_scores_codex":[0.9999706,0.000002293169,0.000001512767,0.000008390313,0.0000138935,0.00000321321],"domain_scores_gemma":[0.9999861,0.000004679182,0.000001466688,0.000001293687,0.000003254642,0.000003313591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001288701,0.0001022693,0.0001256556,0.001393543,0.00001250314,0.0003085321,0.0002058534,0.000525455,0.3301145,0.03386057,0.04486043,0.5883617],"study_design_scores_gemma":[0.000009801632,0.0001122564,0.0004761288,0.0001895445,0.00001125836,0.0007034339,0.00004155538,0.0004560396,0.0359025,0.005981136,0.9561052,0.00001105386],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02507864,0.4839795,0.04104224,0.00400057,0.006112255,0.0001422931,0.0006673621,0.001116114,0.4378611],"genre_scores_gemma":[0.04546359,0.2571031,0.02675538,0.001957481,0.001403891,0.000141084,0.0005815593,0.0002975717,0.6662964],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008380532,"threshold_uncertainty_score":0.0280357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01573947684445976,"score_gpt":0.2372669011084928,"score_spread":0.221527424264033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}