{"id":"W2946159232","doi":"10.1039/c9en00183b","title":"Acquisition of cancer stem cell-like properties in human small airway epithelial cells after a long-term exposure to carbon nanomaterials","year":2019,"lang":"en","type":"article","venue":"Environmental Science Nano","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Institutes of Health","keywords":"SNAI1; Epithelial–mesenchymal transition; Cancer stem cell; Malignant transformation; Cancer research; Carcinogen; DNA damage; Cell biology; Chemistry; Stem cell; Downregulation and upregulation; Biology; Gene; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002775892,0.0001733685,0.0003118291,0.0001559986,0.00004451119,0.00002245114,0.0001755265,0.00005791051,0.001098802],"category_scores_gemma":[5.810452e-7,0.0001373434,0.00006387388,0.0001941275,0.0002776957,0.0001115119,0.0001467145,0.00005706099,0.00004919336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004189049,"about_ca_system_score_gemma":0.00007863773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003833812,"about_ca_topic_score_gemma":0.0000978165,"domain_scores_codex":[0.9983687,0.00003256753,0.0003197764,0.0004590019,0.0004546729,0.0003652732],"domain_scores_gemma":[0.9994158,0.000004380428,0.00009958717,0.0003222773,0.000008391299,0.0001495763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002013701,0.0001940596,0.08299088,0.0001032704,0.000004620847,0.00001125276,0.001002698,0.00004404901,0.9126579,4.38367e-7,0.000001806118,0.002787664],"study_design_scores_gemma":[0.0007616216,0.0005005896,0.192939,0.0001196565,0.00002356401,0.000002753534,0.0001425079,0.000002317285,0.8052832,3.859971e-7,0.00008959464,0.0001348867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976865,0.0005325652,0.000001126869,0.00003801614,0.0005071835,0.0008822985,0.00004768315,0.000009895946,0.0002947312],"genre_scores_gemma":[0.9971947,0.00009548993,0.00005646875,0.0001559562,0.00007029677,0.0001053047,0.000003597849,0.00001867867,0.002299473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1099481,"threshold_uncertainty_score":0.9998143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009906881398182172,"score_gpt":0.224309546673373,"score_spread":0.2144026652751908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}