{"id":"W2946164611","doi":"10.3389/fnins.2019.00455","title":"TREML2 Mutation Mediate Alzheimer’s Disease Risk by Altering Neuronal Degeneration","year":2019,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Qingdao Key Health Discipline Development Fund; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Oncology; Dementia; Internal medicine; Cognition; Clinical Dementia Rating; Psychology; Disease; Cerebrospinal fluid; Medicine; Alzheimer's disease; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003160369,0.0002877394,0.0002215145,0.0003498135,0.000289027,0.000211709,0.0005531086,0.0000541418,0.0000534333],"category_scores_gemma":[0.0007066509,0.0003024129,0.0000774189,0.0008517402,0.0001349723,0.00108921,0.0001005424,0.0003241737,0.0001064028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004668728,"about_ca_system_score_gemma":0.00009338908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003621236,"about_ca_topic_score_gemma":0.000002135312,"domain_scores_codex":[0.9964239,0.0005110573,0.0004941795,0.001253151,0.0008055861,0.0005121073],"domain_scores_gemma":[0.9988176,0.00009974992,0.0002810225,0.0004819466,0.00003078136,0.000288942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005804592,0.00006232931,0.004527669,0.000006486096,3.789114e-7,0.00003994443,0.00006811931,0.009258522,0.9810611,0.0006804967,0.001946507,0.002290429],"study_design_scores_gemma":[0.0006977084,0.0001190427,0.007181571,0.00000899845,0.00001212435,0.00001265414,0.00001129115,0.2297972,0.7573379,0.0005508983,0.003929193,0.0003414549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733765,0.00006850236,0.01864289,0.0005432522,0.00607235,0.0007142682,0.00007238594,0.0002018253,0.0003080089],"genre_scores_gemma":[0.9951717,0.0002650812,0.0006438583,0.003234711,0.0000778008,0.00005223164,0.00001461053,0.00004371574,0.0004963503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2237232,"threshold_uncertainty_score":0.9999428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199713623820325,"score_gpt":0.2418995322243139,"score_spread":0.2219281698422814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}