{"id":"W2946204536","doi":"10.1016/j.biopsych.2019.03.881","title":"S130. Synergistic Action of Aripiprazole and Escitalopram Potentiates Medial Prefrontal Cortical Activity Through Blockade of 5-HT2B Receptors","year":2019,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Aripiprazole; Escitalopram; Antidepressant; Pharmacology; Partial agonist; Dopamine receptor D2; Serotonin; 5-HT receptor; Psychology; Context (archaeology); Serotonin reuptake inhibitor; Dopamine; Prefrontal cortex; Neuroscience; Medicine; Receptor; Agonist; Internal medicine; Psychiatry; Biology; Schizophrenia (object-oriented programming); Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001630198,0.000391034,0.0005132006,0.000254549,0.0001694004,0.0002518652,0.0006261644,0.0007279259,0.02247951],"category_scores_gemma":[0.0003839612,0.0001752947,0.000475833,0.0001501638,0.0002369344,0.0003377729,0.0002393459,0.0006361318,0.003116608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004541587,"about_ca_system_score_gemma":0.0007559129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002771599,"about_ca_topic_score_gemma":0.007275599,"domain_scores_codex":[0.9998577,0.00002250446,0.00001607667,0.00001772249,0.0000532813,0.00003276033],"domain_scores_gemma":[0.9998752,0.00001856002,0.00004128546,0.000009633432,0.00002045481,0.00003483232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01030048,0.0006519011,0.0007852442,0.0007635475,0.0003813748,0.001112365,0.0000697531,0.0005121058,0.8503161,0.002918637,0.01041829,0.1217703],"study_design_scores_gemma":[0.01248012,0.02584292,0.07515955,0.0004577723,0.001051254,0.0190442,0.0002332765,0.01337548,0.6636237,0.003489536,0.1850163,0.0002260215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9176714,0.007492651,0.003652302,0.003986393,0.001130892,0.0006035671,0.008265767,0.001059398,0.05613757],"genre_scores_gemma":[0.9745374,0.002978105,0.004114312,0.0008741983,0.0002910508,0.0001410271,0.003768591,0.00006398806,0.01323134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02247951,"threshold_uncertainty_score":0.07520145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03125877332161629,"score_gpt":0.2981958495446246,"score_spread":0.2669370762230083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}