{"id":"W2946218146","doi":"10.1038/s41419-019-1615-0","title":"Smad7:β-catenin complex regulates myogenic gene transcription","year":2019,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; York University","keywords":"Myogenesis; Biology; Cell biology; Chromatin immunoprecipitation; Skeletal muscle; Transcription factor; Chromatin; Myocyte; Beta-catenin; Regulation of gene expression; Transcriptional regulation; Catenin; Reporter gene; Gene; Gene expression; Signal transduction; Wnt signaling pathway; Promoter; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004503639,0.0001581001,0.0001101596,0.00002975405,0.00006943697,0.00003358596,0.0001153288,0.00006743659,0.0001472042],"category_scores_gemma":[0.00001742781,0.0001531538,0.00009958242,0.00003499246,0.00004467869,0.000004701854,0.00004109777,0.00003516797,0.00006910971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006413348,"about_ca_system_score_gemma":0.00008902438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005306365,"about_ca_topic_score_gemma":9.952399e-7,"domain_scores_codex":[0.9991317,0.00003354395,0.000139777,0.0003766113,0.00009766574,0.0002207098],"domain_scores_gemma":[0.9991918,0.000005977405,0.00003944424,0.0002940163,0.00003676024,0.00043196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002771546,0.000106461,0.01955878,0.00008563701,0.00001991501,0.000006309237,0.000018442,0.0001049128,0.9784566,0.00003146545,0.0009186064,0.0004157076],"study_design_scores_gemma":[0.002450921,0.000236653,0.1957881,0.00002818619,0.0002046507,0.000006736469,0.00005279766,0.0009005472,0.7744913,0.0005247106,0.02464145,0.0006739906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923956,0.00642841,0.0001452993,0.0000396715,0.00008420778,0.0002011467,0.00006726083,0.00002730636,0.0006110898],"genre_scores_gemma":[0.9963483,0.000109309,0.0002579549,0.0003131966,0.0001189399,0.00001641038,0.0007470737,0.00002428485,0.00206452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2039654,"threshold_uncertainty_score":0.6245431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01231532863356638,"score_gpt":0.2166699510919488,"score_spread":0.2043546224583825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}