{"id":"W2946234641","doi":"10.1016/s2213-2600(19)30139-0","title":"Nintedanib in combination with pemetrexed and cisplatin for chemotherapy-naive patients with advanced malignant pleural mesothelioma (LUME-Meso): a double-blind, randomised, placebo-controlled phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Medicine; Pemetrexed; Nintedanib; Mesothelioma; Cisplatin; Placebo; Internal medicine; Oncology; Chemotherapy; Double blind; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006532347,0.0002846921,0.0009727941,0.0001644869,0.00007718206,0.00001267205,0.0001128511,0.00006217803,0.0001686815],"category_scores_gemma":[0.0001056495,0.0001385098,0.0000644856,0.0002195106,0.0002092846,0.0001191002,0.00001797044,0.0001632949,0.000005930618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009091989,"about_ca_system_score_gemma":0.00007065028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000191181,"about_ca_topic_score_gemma":0.00001891339,"domain_scores_codex":[0.9982381,0.0001079883,0.0004457137,0.0003643544,0.0005407673,0.0003030312],"domain_scores_gemma":[0.9987564,0.0004108224,0.0002909862,0.0003187979,0.00009416402,0.0001288125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9596077,0.0006730674,0.03517111,0.0001059268,0.0001938434,0.000007754496,0.0003386084,0.00002944449,0.001329912,0.00009353122,0.0002341732,0.002214944],"study_design_scores_gemma":[0.9445907,0.01288923,0.03949866,0.0004161096,0.000298257,0.000003506142,0.0002108842,0.0004249278,0.0003905272,0.00003567426,0.001058834,0.0001826907],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870479,0.000418865,0.00006804074,0.001410802,0.0001067196,0.01041052,0.00002969621,0.0000348206,0.0004726657],"genre_scores_gemma":[0.996637,0.00002490519,0.0001144398,0.0015514,0.0003077568,0.0009103228,0.0001549248,0.00003612815,0.000263063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01501698,"threshold_uncertainty_score":0.5648265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02779761725672492,"score_gpt":0.3120703873994524,"score_spread":0.2842727701427274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}