{"id":"W2946234641","doi":"10.1016/s2213-2600(19)30139-0","title":"Nintedanib in combination with pemetrexed and cisplatin for chemotherapy-naive patients with advanced malignant pleural mesothelioma (LUME-Meso): a double-blind, randomised, placebo-controlled phase 3 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Respiratory Medicine","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Medicine; Pemetrexed; Nintedanib; Mesothelioma; Cisplatin; Placebo; Internal medicine; Oncology; Chemotherapy; Double blind; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001364224,0.001999016,0.004254494,0.0004238783,0.000502864,0.001140487,0.001238045,0.001993372,0.006331351],"category_scores_gemma":[0.001450999,0.0009705464,0.002597453,0.0004402005,0.001531062,0.001455434,0.0004802516,0.004128873,0.00132411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00077249,"about_ca_system_score_gemma":0.0008932273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001314431,"about_ca_topic_score_gemma":0.002872848,"domain_scores_codex":[0.9995034,0.0002471191,0.00003109781,0.0001030965,0.00003331799,0.00008189635],"domain_scores_gemma":[0.9994124,0.000153769,0.0001146253,0.00005049737,0.00003878349,0.0002299114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.984217,0.002952439,0.0002508999,0.0008723068,0.0009463117,0.00003125719,0.00003943855,0.0002282431,0.001839148,0.00007502616,0.0006525019,0.007895315],"study_design_scores_gemma":[0.9693168,0.02919077,0.0005793142,0.00002239608,0.0002419348,0.00001508502,0.00001179358,0.0001361811,0.0001134276,0.00005860427,0.0003048986,0.000008732522],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763022,0.01188074,0.000944024,0.001165043,0.001814294,0.004119095,0.001184496,0.0002113957,0.002378669],"genre_scores_gemma":[0.9779087,0.006907108,0.001438763,0.001664515,0.0007613596,0.004018817,0.001325244,0.00003815263,0.005937393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006331351,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02779761725672492,"score_gpt":0.3120703873994524,"score_spread":0.2842727701427274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}