{"id":"W2946237993","doi":"10.3390/cancers11050693","title":"Modulating PKCα Activity to Target Wnt/β-Catenin Signaling in Colon Cancer","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology","funders":"Direction Générale de l’offre de Soins; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Ligue Contre le Cancer; Fondation ARC pour la Recherche sur le Cancer","keywords":"Wnt signaling pathway; Protein kinase C; Catenin; Cancer research; Beta-catenin; Colorectal cancer; Signal transduction; Adenomatous polyposis coli; Biology; Chemistry; Cell biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002254644,0.0002124228,0.0002313903,0.00008163803,0.00005802345,0.0000275911,0.0002445979,0.0001560132,0.0003783911],"category_scores_gemma":[0.00003038702,0.0002241323,0.00006878674,0.0002662901,0.00003183944,0.00001005019,0.0001084323,0.0001462634,0.00004357367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006073007,"about_ca_system_score_gemma":0.00061296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006772038,"about_ca_topic_score_gemma":0.00025842,"domain_scores_codex":[0.9985721,0.00004336208,0.0002116847,0.000542342,0.0001842879,0.0004461961],"domain_scores_gemma":[0.9995189,0.0000139247,0.00009291138,0.0001880993,0.00007407373,0.0001121237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001819358,0.000007081462,0.01906167,0.00002572353,0.0000360055,0.000003325125,0.0002019143,0.09226102,0.8845609,0.000008638483,0.001075125,0.002576639],"study_design_scores_gemma":[0.0007584572,0.0001224546,0.00407291,0.0001115805,0.000008652825,0.000001907634,0.0001056516,0.001160574,0.9786376,0.00004310979,0.01452575,0.0004513414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963974,0.0005982117,0.0002832886,0.0001747818,0.0006614213,0.0003756344,0.00001436879,0.00002124954,0.001473643],"genre_scores_gemma":[0.9948652,0.00006641548,0.001001416,0.0005621589,0.000261798,0.0001783714,0.00002796834,0.00004036602,0.002996265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09407669,"threshold_uncertainty_score":0.9139852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147230021854569,"score_gpt":0.2646434646474852,"score_spread":0.2531711644289396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}