{"id":"W2946237993","doi":"10.3390/cancers11050693","title":"Modulating PKCα Activity to Target Wnt/β-Catenin Signaling in Colon Cancer","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology","funders":"Direction Générale de l’offre de Soins; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Ligue Contre le Cancer; Fondation ARC pour la Recherche sur le Cancer","keywords":"Wnt signaling pathway; Protein kinase C; Catenin; Cancer research; Beta-catenin; Colorectal cancer; Signal transduction; Adenomatous polyposis coli; Biology; Chemistry; Cell biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001653689,0.0004152853,0.0003779712,0.0004186969,0.0001576115,0.000330628,0.0002047653,0.0002752516,0.001029947],"category_scores_gemma":[0.0001093338,0.0001769858,0.0002646334,0.0003296442,0.0001960409,0.0002183949,0.0001905977,0.0007471492,0.0004046635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004324198,"about_ca_system_score_gemma":0.0002731099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005851008,"about_ca_topic_score_gemma":0.001254273,"domain_scores_codex":[0.9998574,0.00001696479,0.00001799593,0.00003067886,0.00003558928,0.00004127228],"domain_scores_gemma":[0.9999233,0.000007342976,0.00002297453,0.00001090421,0.00001090455,0.00002450522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004125807,0.0001275308,0.0002249832,0.0001456749,0.00001199299,0.00006035542,0.00001031849,0.0002001111,0.9951289,0.00005976842,0.00006319345,0.003554618],"study_design_scores_gemma":[0.0001408988,0.001195745,0.003149762,0.0000129835,0.00005268971,0.0003026889,0.00002390265,0.0008600994,0.9894532,0.00004464142,0.004756076,0.000007187232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819646,0.01279166,0.002532215,0.0002696934,0.0001683402,0.0001434446,0.0003787975,0.0001501094,0.001601038],"genre_scores_gemma":[0.9866724,0.008391306,0.002123874,0.00008210076,0.00002359861,0.00007861,0.0003582397,0.00002039051,0.00224936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001029947,"threshold_uncertainty_score":0.003445506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147230021854569,"score_gpt":0.2646434646474852,"score_spread":0.2531711644289396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}