{"id":"W2946243434","doi":"10.1016/j.ccell.2019.04.004","title":"Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":261,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University Health Centre; Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research; Jewish General Hospital; McGill University","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Baylor College of Medicine; Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Alex's Lemonade Stand Foundation for Childhood Cancer; Genome Canada; Bear Necessities Pediatric Cancer Foundation; National Institute of Allergy and Infectious Diseases; Cancer Prevention and Research Institute of Texas; Génome Québec; Children's Brain Tumor Foundation","keywords":"Chromatin; Histone; Biology; Epigenomics; Cancer research; Acetylation; Epigenetics; Histone deacetylase; Enhancer; DNA methylation; Genetics; DNA; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001991215,0.0001296123,0.0001379983,0.0000475691,0.00004208352,0.00001642402,0.0001214892,0.0001402175,0.0001868289],"category_scores_gemma":[0.00002786452,0.0001230142,0.00004020959,0.0001257041,0.00004645143,0.000006300942,0.000115657,0.0001215598,0.00004630435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001229573,"about_ca_system_score_gemma":0.0001077868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002069801,"about_ca_topic_score_gemma":0.0004257657,"domain_scores_codex":[0.9988761,0.0001047185,0.0001546177,0.0004604654,0.0001539629,0.0002501212],"domain_scores_gemma":[0.9994139,0.000019196,0.00003439121,0.000356831,0.00007399137,0.0001016995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001457199,0.00004183746,0.01085335,0.00005563497,0.000003327438,0.000001238287,0.000388862,0.0002669221,0.9861661,0.000002397468,0.000549072,0.001525504],"study_design_scores_gemma":[0.0006681143,0.0001815622,0.004710844,0.00003102578,0.000002996235,0.000001371089,0.0001196388,0.0001068981,0.984786,0.00001154888,0.009221287,0.0001586584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942647,0.003429369,0.00004501239,0.0001687157,0.0001291649,0.0004720061,0.00001303312,0.000007878041,0.001470072],"genre_scores_gemma":[0.9975859,0.0001508544,0.00008100237,0.0001596115,0.0001020337,0.00009656962,0.00001906701,0.0000211519,0.001783795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008672214,"threshold_uncertainty_score":0.5016375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258362955478095,"score_gpt":0.300613097657726,"score_spread":0.2880294681029451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}