{"id":"W2946243434","doi":"10.1016/j.ccell.2019.04.004","title":"Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":261,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University Health Centre; Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research; Jewish General Hospital; McGill University","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Baylor College of Medicine; Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Alex's Lemonade Stand Foundation for Childhood Cancer; Genome Canada; Bear Necessities Pediatric Cancer Foundation; National Institute of Allergy and Infectious Diseases; Cancer Prevention and Research Institute of Texas; Génome Québec; Children's Brain Tumor Foundation","keywords":"Chromatin; Histone; Biology; Epigenomics; Cancer research; Acetylation; Epigenetics; Histone deacetylase; Enhancer; DNA methylation; Genetics; DNA; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000823001,0.0002088343,0.0001799,0.0002893087,0.0001858511,0.0003657448,0.0001691509,0.0002177208,0.002547753],"category_scores_gemma":[0.0001407996,0.0001382045,0.0001941097,0.0002400011,0.0002461263,0.0001506372,0.0002646958,0.0004371485,0.0004158361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003035476,"about_ca_system_score_gemma":0.0002300599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067415,"about_ca_topic_score_gemma":0.001233307,"domain_scores_codex":[0.9999008,0.00001063921,0.000005974704,0.00002083096,0.00002500402,0.0000367671],"domain_scores_gemma":[0.9999088,0.000007350633,0.00003427199,0.00001340564,0.000008631822,0.00002749222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006360857,0.00007995222,0.003832957,0.00003226101,0.00004091879,0.001816232,0.00002877223,0.0002398728,0.9857844,0.0006196477,0.0003458631,0.006543037],"study_design_scores_gemma":[0.00007925175,0.001072493,0.1274387,0.00001386642,0.0001431712,0.02306392,0.0003616353,0.002303704,0.8364885,0.001494927,0.007517351,0.00002248271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959608,0.0005506428,0.000961479,0.000140602,0.0000164669,0.0000113662,0.0002421986,0.00008743949,0.002029098],"genre_scores_gemma":[0.9986921,0.0001927731,0.0001394468,0.00001919105,0.000003380249,0.000003094829,0.0001053595,0.00001332411,0.0008315043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002547753,"threshold_uncertainty_score":0.008523047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258362955478095,"score_gpt":0.300613097657726,"score_spread":0.2880294681029451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}