{"id":"W2946303018","doi":"10.3390/cancers11050705","title":"LOXL1 Is Regulated by Integrin α11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Cancer Council NSW; National Health and Medical Research Council; Cancer Institute NSW; Canadian Institutes of Health Research; Terry Fox Foundation; Ontario Ministry of Health and Long-Term Care; Canadian Cancer Society","keywords":"Lysyl oxidase; Integrin; Cancer research; Stromal cell; Carcinogenesis; Lung cancer; Stroma; Metastasis; Collagen receptor; Biology; Gene knockdown; Pathology; Cancer; Medicine; Cell; Extracellular matrix; Immunology; Immunohistochemistry; Cell biology; Cell culture; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006183666,0.000141881,0.0001393815,0.00001946978,0.00003955249,0.00001506801,0.0000952906,0.000126885,0.000198149],"category_scores_gemma":[0.000005549904,0.0001313017,0.00004340798,0.00006776973,0.00003614322,0.000004517628,0.00005289293,0.00008990269,0.00001122231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007980043,"about_ca_system_score_gemma":0.0001771977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001129021,"about_ca_topic_score_gemma":0.0001170667,"domain_scores_codex":[0.9992527,0.00001759685,0.0001175624,0.0003525751,0.00005036316,0.0002091704],"domain_scores_gemma":[0.9996015,0.00000252902,0.00006074349,0.0002125559,0.00004998195,0.00007271697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005411249,0.000005310934,0.003327193,0.00006664227,0.00002626576,2.609449e-7,0.0001041502,0.00004291446,0.9171075,0.000001566894,0.07863146,0.0006326303],"study_design_scores_gemma":[0.0005438446,0.00007456143,0.001317021,0.00002756634,0.00003153393,0.000001793116,0.00004494918,0.0003069032,0.8969579,0.000003290332,0.1004985,0.0001920496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933436,0.004905821,0.0001615747,0.00006936855,0.0005930329,0.000264109,0.0001151148,0.0000106212,0.0005367645],"genre_scores_gemma":[0.9901705,0.001123663,0.00007809783,0.0005511896,0.0002022508,0.00002392803,0.00007487107,0.00002277188,0.007752673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02186708,"threshold_uncertainty_score":0.5354326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004047541608661504,"score_gpt":0.2076170055222787,"score_spread":0.2035694639136172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}