{"id":"W2946303018","doi":"10.3390/cancers11050705","title":"LOXL1 Is Regulated by Integrin α11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Cancer Council NSW; National Health and Medical Research Council; Cancer Institute NSW; Canadian Institutes of Health Research; Terry Fox Foundation; Ontario Ministry of Health and Long-Term Care; Canadian Cancer Society","keywords":"Lysyl oxidase; Integrin; Cancer research; Stromal cell; Carcinogenesis; Lung cancer; Stroma; Metastasis; Collagen receptor; Biology; Gene knockdown; Pathology; Cancer; Medicine; Cell; Extracellular matrix; Immunology; Immunohistochemistry; Cell biology; Cell culture; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001204821,0.0001716566,0.0001658435,0.00019976,0.0001382219,0.0003131071,0.00007805265,0.0001619667,0.001071823],"category_scores_gemma":[0.0001160489,0.00008796767,0.0001435439,0.0001192918,0.000147977,0.00009197003,0.0001185491,0.0003299696,0.0002516557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000250276,"about_ca_system_score_gemma":0.0001707645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005450298,"about_ca_topic_score_gemma":0.0009359497,"domain_scores_codex":[0.999922,0.00001306142,0.000006657305,0.0000147197,0.00002041124,0.00002316123],"domain_scores_gemma":[0.9998896,0.0000142568,0.00004807249,0.000006240828,0.00001238569,0.00002939067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001258853,0.00002845464,0.001631806,0.00002352902,0.000003110874,0.0001158709,0.00001393431,0.00003653857,0.9969036,0.00005743842,0.00005010814,0.001009805],"study_design_scores_gemma":[0.00003399264,0.0004720863,0.06062327,0.000008829166,0.00002615923,0.001171518,0.0001284377,0.001646673,0.9320166,0.00008166007,0.003784659,0.000006207641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971514,0.001256849,0.0007529344,0.00009501898,0.000008926841,0.000009503407,0.0001798548,0.00003285428,0.0005127136],"genre_scores_gemma":[0.9979086,0.0003868892,0.000286677,0.0000237717,0.000002798794,0.000007833924,0.0002542975,0.000005194704,0.001123855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001071823,"threshold_uncertainty_score":0.003585577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004047541608661504,"score_gpt":0.2076170055222787,"score_spread":0.2035694639136172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}